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  1. No Access

    Article

    Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics

    Reactive oxygen species (ROS) and antioxidants are essential to maintain a redox balance within tissues and cells. Intracellular ROS regulate key cellular functions such as proliferation, differentiation and a...

    Wanakee J. Carr, Rebecca E. Oberley-Deegan, Yu** Zhang… in Histochemistry and Cell Biology (2011)

  2. No Access

    Chapter

    The Adventures of Superoxide Dismutase in Health and Disease: Superoxide in the Balance

    This chapter focuses on superoxide dismutases (SOD), a group of enzymes important for removing biologically generated superoxide anion radical (O2 .−). These enzymes function by catalyzing th...

    Kristy M. Powers, Larry W. Oberley, Frederick E. Domann in Oxidants in Biology (2008)

  3. No Access

    Article

    Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

    Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1α subunit and an HI...

    Min Wang, Jeanie S Kirk, Sujatha Venkataraman, Frederick E Domann… in Oncogene (2005)

  4. No Access

    Article

    Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells

    This study investigates the role of the antioxidant enzyme manganese superoxide dismutase (MnSOD) in androgen-independent human prostate cancer (PC-3) cells' growth rate in vitro and in vivo. MnSOD levels were fo...

    Sujatha Venkataraman, **aohong Jiang, Christine Weydert, Yu** Zhang… in Oncogene (2005)

  5. No Access

    Article

    Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1

    Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expres...

    Stephen R Plymate, Kathy H Haugk, Cynthia C Sprenger, Peter S Nelson… in Oncogene (2003)

  6. No Access

    Article

    Overexpression of Glia Maturation Factor in C6 Cells Promotes Differentiation and Activates Superoxide Dismutase

    In order to evaluate the intracellular function of glia maturation factor (GMF), we overexpressed GMF in C6 rat glioma cells using two methods: stable transfection using the pcDNA3 plasmid, and transient trans...

    Ramon Lim, Asgar Zaheer, Jeff A. Kraakevik, Christine J. Darby… in Neurochemical Research (1998)

  7. No Access

    Article

    Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase

    Larry W. Oberley in AGE (1998)

  8. No Access

    Article

    Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase

    Manganese superoxide dismutase (MnSOD) has been previously shown to suppress the malignant phenotype of human melanoma and breast cancer cells. To test the possible role of MnSOD in glioma malignancy, MnSOD wa...

    Weixiong Zhong, Larry W Oberley, Terry D Oberley, Daret K St Clair in Oncogene (1997)

  9. No Access

    Article

    Immunohistochemical localization of antioxidant enzymes during hamster kidney development

    Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...

    Terry D. Oberley, Joan M. Sempf, Larry W. Oberley in The Histochemical Journal (1995)

  10. No Access

    Article

    Immunohistochemical localization of antioxidant enzymes during hamster kidney development

    Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...

    Terry D. Oberley, Joan M. Sempf, Larry W. Oberley in The Histochemical Journal (1995)

  11. No Access

    Article

    Immunolocalization of antioxidant enzymes in adult hamster kidney

    Immunoperoxidase and immunogold techniques were used to localize the following antioxidant enzyme systems in the adult hamster kidney at the light and ultrastructural levels: superoxide dismutases, catalases, ...

    Kenneth E. Muse, Terry D. Oberley, Joan M. Sempf… in The Histochemical Journal (1994)

  12. No Access

    Article

    Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme

    The localization of manganese superoxide dismutase (MnSOD) was determined using immunohistochemistry of various tissues of normal and transgenic mice which express the human enzyme, with emphasis on studies of...

    Terry D. Oberley, Douglas B. Coursin, Herbert P. Cihla… in The Histochemical Journal (1993)

  13. No Access

    Article

    In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium

    The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma tissues and in cultured human renal adenocarcinoma...

    An Hang Yang, Terry D. Oberley… in In Vitro Cellular & Developmental Biology (1987)

  14. No Access

    Article

    Kidney glomerular explants in serum-free media: Demonstration of intracellular antioxidant enzymes and active oxygen metabolites

    Guinea pig glomeruli were grown for 22 d in a serum-free medium composed of Waymouth's MB 752/1 supplemented with sodium pyruvate, nonessential amino acids, and antibiotics (the basic medium). Intracellular ce...

    Bruce W. Steinert, Paul J. Anderson… in In Vitro Cellular & Developmental Biology (1986)