9 Result(s)
within
Rebecca E. Oberley-Deegan
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Article
Encapsulation of Manganese Porphyrin in Chondroitin Sulfate-A Microparticles for Long Term Reactive Oxygen Species Scavenging
Oxidative stress due to excess reactive oxygen species (ROS) is related to many chronic illnesses including degenerative disc disease and osteoarthritis. MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin analog, is ...
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Article
Open AccessProstate cancer addiction to oxidative stress defines sensitivity to anti-tumor neutrophils
Bone metastatic prostate cancer (BM-PCa) remains one of the most difficult cancers to treat due to the complex interactions of cancer and stromal cells. We previously showed that bone marrow neutrophils elicit...
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Article
Open AccessUpregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction
A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. While there are a small number of studies sugge...
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Article
Open AccessAdipocytes protect fibroblasts from radiation-induced damage by adiponectin secretion
Prostate and colon cancers are among the most common cancers diagnosed annually, and both often require treatment with radiation therapy. Advancement in radiation delivery techniques has led to highly accurate...
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Article
Open AccessMnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer
Treatment of differentiated thyroid cancer often involves administration of radioactive iodine (I-131) for remnant ablation or adjuvant therapy. However, there is morbidity associated with I-131 therapy, which...
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Article
Open AccessImpact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection
Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re...
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Article
Open AccessThe ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis
Radiodermatitis is a painful side effect for cancer patients undergoing radiotherapy. Irradiation of the skin causes inflammation and breakdown of the epidermis and can lead to significant morbidity and mortal...
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Chapter
Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells
This chapter explores the role that metalloporphyrins (MnTE-2-PyP, MnTnBuOE-2-PyP, and MnTnHex-2-PyP) play in cancer growth and progression. This review focuses on the effect that metalloporphyrins have on sig...
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Article
Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics
Reactive oxygen species (ROS) and antioxidants are essential to maintain a redox balance within tissues and cells. Intracellular ROS regulate key cellular functions such as proliferation, differentiation and a...
