14 Result(s)
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Sujatha Venkataraman
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Article
Open AccessRapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy
Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchron...
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Open AccessCellular Therapy for Children with Central Nervous System Tumors: Mining and Map** the Correlative Data
Correlative studies should leverage clinical trial frameworks to conduct biospecimen analyses that provide insight into the bioactivity of the intervention and facilitate iteration toward future trials that fu...
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Open AccessComprehensive molecular characterization of pediatric radiation-induced high-grade glioma
Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing on 32 RIG tumors and an in vitro...
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Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine
MYC-driven medulloblastomas are highly aggressive childhood tumors with dismal outcomes and a lack of new treatment paradigms. We identified that targeting replication stress through WEE1 inhibition to suppres...
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Correction: BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway
The original version of this Article omitted the following from the Acknowledgements: This work was supported by the Luke’s Army Pediatric Cancer Research Fund St. Baldrick’s Scholar Award. This has now been c...
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BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway
High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and ro...
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Article
Open AccessCombined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma
Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulate...
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Open AccessPolo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive, fatal, childhood tumors that arise in the brainstem. DIPGs have no effective treatment, and their location and diffuse nature render them inoper...
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Open AccessIntegrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with signifi...
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Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells
Medulloblastoma accounts for 20 % of all primary pediatric intracranial tumors. Current treatment cures 50–80 % of patients but is associated with significant long-term morbidity and thus new therapeutic targe...
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Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells
Atypical teratoid/rhabdoid tumors (ATRT) are rare, highly malignant, embryonal CNS tumors with a poor prognosis. Therapy relies on highly toxic chemotherapy and radiotherapy. To improve outcomes and decrease m...
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Open AccessPolo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
Medulloblastoma is the most common malignant brain tumor in children and remains a therapeutic challenge due to its significant therapy-related morbidity. Polo-like kinase 1 (PLK1) is highly expressed in many can...
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Article
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1α subunit and an HI...
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Article
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells
This study investigates the role of the antioxidant enzyme manganese superoxide dismutase (MnSOD) in androgen-independent human prostate cancer (PC-3) cells' growth rate in vitro and in vivo. MnSOD levels were fo...
