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Article
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities during development and early adulthood, but had a reduced lifespan and increased incidence of neoplastic changes in the liver...
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Article
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1
Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expres...
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Article
Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model
Previous studies in our laboratories demonstrated that overexpression of manganese superoxide dismutase (MnSOD) suppressed both the incidence and multiplicity of papillomas in a DMBA/TPA multi-stage skin carci...
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Article
Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase
Manganese superoxide dismutase (MnSOD) has been previously shown to suppress the malignant phenotype of human melanoma and breast cancer cells. To test the possible role of MnSOD in glioma malignancy, MnSOD wa...
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Article
Immunohistochemical localization of antioxidant enzymes during hamster kidney development
Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...
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Article
Immunohistochemical localization of antioxidant enzymes during hamster kidney development
Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...
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Article
Immunolocalization of antioxidant enzymes in adult hamster kidney
Immunoperoxidase and immunogold techniques were used to localize the following antioxidant enzyme systems in the adult hamster kidney at the light and ultrastructural levels: superoxide dismutases, catalases, ...
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Article
In vitro characterization of estrogen induced syrian hamster renal tumors: Comparison with an immortalized cell line derived from diethylstilbestrol-treated adult hamster kidney
Primary diethylstilbestrol-induced kidney tumors from Syrian hamsters were grown in vitro and maintained in culture for 6 mo. Combined immunohistochemical studies using antibodies to intermediate filaments and...
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Article
Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme
The localization of manganese superoxide dismutase (MnSOD) was determined using immunohistochemistry of various tissues of normal and transgenic mice which express the human enzyme, with emphasis on studies of...
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Article
Establishment and characterization of a SV40 T-antigen immortalized human bronchial epithelial cell line
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Article
Progressive renal insufficiency in methylmalonic acidemia
Methylmalonic acidemia is a heterogeneous inborn error of propionate metabolism. Therapy frequently includes a low-protein diet to minimize precursors of methylmalonic acid (MMA) and reduce its concentration i...
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Article
Role of antioxidant enzymes in cell immortalization and transformation
The role of antioxidant enzymes, particularly superoxide dismutase (SOD), in immortalization and malignant transformation is discussed. SOD (generally MnSOD) has been found to be lowered in a wide variety of t...
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Article
In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium
The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma tissues and in cultured human renal adenocarcinoma...
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Article
Effect of interferon alpha, interferon beta, and interferon gamma on the in vitro growth of human renal adenocarcinoma cells
Interferon-α, interferon-β, and interferon-γ differ in their antiproliferative effects for several cell lines. Interferons were thus assessed for their activity in inhibiting proliferation of three renal cell car...
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Article
In vitro growth and differentiation of human kidney tubular cells on a basement membrane substrate
Kidney cortical tubular cells, mainly proximal tubular cells, isolated from human kidney and grown either on a basement membrane substrate in chemically defined medium or on plastic in serum-supplemented mediu...
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Article
Kidney glomerular expiants in serum-free media: role of individual medium components in cell outgrowth
Guinea pig glomeruli were grown for 22 days in a serum-free medium composed of Waymouth’s MB 752/1 supplemented with sodium pyruvate, nonessential amino acids, and antibiotics. To this basic medium was added i...
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Article
Kidney glomerular explants in serum-free media
Guinea pig glomeruli were grown in vitro for 22 days in a serum-free medium composed of Waymouth’s MB 752/1 supplemented with sodium pyruvate, nonessential amino acids, antibiotics, insulin, transferrin, selen...
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Article
Kidney glomerular explants in serum-free media: Demonstration of intracellular antioxidant enzymes and active oxygen metabolites
Guinea pig glomeruli were grown for 22 d in a serum-free medium composed of Waymouth's MB 752/1 supplemented with sodium pyruvate, nonessential amino acids, and antibiotics (the basic medium). Intracellular ce...
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Article
Anticancer activity of metal compounds with superoxide dismutase activity
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Article
Pharmacologic activities of copper compounds in chronic diseases
Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypo...
