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Article
PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression
Androgen deprivation therapy (ADT) is the first line of treatment for metastatic prostate cancer (PCa) that effectively delays the tumor progression. However, it also increases the risk of venous thrombosis ev...
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Article
Open AccessDPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the ne...
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Article
Chaperone-mediated autophagy promotes PCa survival during ARPI through selective proteome remodeling
The androgen receptor (AR) plays an important role in PCa metabolism, with androgen receptor pathway inhibition (ARPI) subjecting PCa cells to acute metabolic stress caused by reduced biosynthesis and energy p...
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Article
Open AccessCRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
Prostate cancer harboring BRCA1/2 mutations are often exceptionally sensitive to PARP inhibitors. However, genomic alterations in other DNA damage response genes have not been consistently predictive of clinical ...
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Article
Open AccessReformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we show that changes in chondroi...
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Article
Open AccessThe different prognostic significance of polysialic acid and CD56 expression in tumor cells and lymphocytes identified in breast cancer
Protein glycosylation, the attachment of carbohydrates onto proteins, is a fundamental process that alters the biological activity of proteins. Changes to glycosylation states are associated with many forms of...
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Article
Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer
Cell division cycle-associated 8 (CDCA8) is a component of chromosomal passenger complex (CPC) that participates in mitotic regulation. Although cancer-related CDCA8 hyperactivation has been widely observed, i...
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Article
Open AccessMenin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity
Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We previously showed that heat shock protein 27 (HSP27) acte...
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Article
Open AccessHigh fibroblast-activation-protein expression in castration-resistant prostate cancer supports the use of FAPI-molecular theranostics
To evaluate fibroblast-activation-protein (FAP) expression in different clinical stages of prostate cancer (PC) with regards to utility of [68 Ga]Ga-FAPI-04 PET/CT imaging in patients with castration-resistant PC...
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Article
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype. Here we investigated such a phenomenon in prostate cancer, in which tumours can escape epithelial lineage confinement a...
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Article
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation
Dysregulated translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Here, we report that enhancer of zeste homologue 2 (EZH2), pr...
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Article
Open AccessA noncanonical AR addiction drives enzalutamide resistance in prostate cancer
Resistance to next-generation anti-androgen enzalutamide (ENZ) constitutes a major challenge for the treatment of castration-resistant prostate cancer (CRPC). By performing genome-wide ChIP-seq profiling in EN...
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Article
Open AccessPlasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer
Molecular stratification can improve the management of advanced cancers, but requires relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a recent expansion of treatment op...
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Article
Open AccessHistone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells
The DNA damage response (DDR) pathway is a promising target for anticancer therapies. The androgen receptor and myeloblastosis transcription factors have been reported to regulate expression of an overlap** ...
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Article
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer
B lymphoma Mo-MLV insertion region 1 (BMI1) has been reported to be an oncoprotein. BMI1 represses tumor suppressors to promote cell proliferation, epithelial-mesenchymal transition (EMT), and cancer progressi...
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Article
Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer
Deregulated expression of circular RNAs (circRNAs) is associated with various human diseases, including many types of cancer. Despite their growing links to cancer, there has been limited characterization of c...
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Article
Open AccessAbi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling
Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a memb...
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Article
Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal ph...
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Article
Open AccessAuthor Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper
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Article
Open AccessCorrection: A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome
Following the publication of the above article, the authors noted an error in Figure 4, panel B. The colours of the localized and mCRPC samples were accidentally switched. The authors have corrected the colour...
