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Article
Open AccessDesigning a novel and combinatorial multi-antigenic epitope-based vaccine “MarVax” against Marburg virus—a reverse vaccinology and immunoinformatics approach
Marburg virus (MARV) is a member of the Filoviridae family and causes Marburg virus disease (MVD) among humans and primates. With fatality rates going up to 88%, there is currently no commercialized cure or va...
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Article
Geodesically completing regular black holes by the Simpson–Visser method
Regular black holes are often geodesically incomplete when their extensions to negative values of the radial coordinate are considered. Here, we propose to use the Simpson–Visser method of regularising a singu...
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Article
Open AccessAssociated production of Higgs and single top at the LHC in presence of the SMEFT operators
We analyse the single top production in association with the Higgs at the Large Hadron Collider (LHC) using Standard Model (SM) effective operators upto dimension six. We show that the presence of effective op...
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Article
Understanding the Molecular Regulation of Serotonin Receptor 5-HTR1B-β-Arrestin1 Complex in Stress and Anxiety Disorders
The serotonin receptor subtype 5-HTR1B is widely distributed in the brain with an important role in various behavioral implications including neurological conditions and psychiatric disorders. The neuromodulatory...
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Article
Open AccessRegularizing the JNW and JMN naked singularities
We extend the method of Simpson and Visser (SV) of regularizing a black hole spacetime, to cases where the initial metric represents a globally naked singularity. We choose two particular geometries, the Janis...
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Article
Exploring the pharmacological aspects of natural phytochemicals against SARS-CoV-2 Nsp14 through an in silico approach
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), possesses an important bifunctional nonstructural protein (nsp14) with a C-terminal N7-methyltransferase (N7-MTase) domain and an N-terminal do...
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Chapter
Elucidating the Role of miRNA in Inflammasome-Mediated Immune Response in Leishmaniasis
The inflammasome is a cell cytoplasm-localized multimeric protein complex of host defense mechanism which gets activated due to infection in the innate immune system via pathogens or due to receiving cell dama...
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Article
miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer
Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests that fine balance between anti-angiogenic microRNA (miRNA) and...
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Article
Open AccessDisformal transformations and the motion of a particle in semi-classical gravity
The approach to incorporate quantum effects in gravity by replacing free particle geodesics with Bohmian non-geodesic trajectories has an equivalent description in terms of a conformally related geometry, wher...
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Chapter and Conference Paper
Challenges Against DENV3 Vaccines: A Bioinformatic Approach
Dengue virus (DENV) causes significant mortality as well as co-morbidity in tropical and subtropical countries, causing huge number of infections every year. Dengue can cause a different disease, starting from...
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Article
Open AccessCollapse in f(R) gravity and the method of R matching
Collapsing solutions in f(R) gravity are restricted due to junction conditions that demand continuity of the Ricci scalar and its normal derivative across the time-like collapsing hypersurface. These are obtained...
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Article
A complex structure of arrestin-2 bound to a G protein-coupled receptor
Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs), which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin, arrestins 2 and 3 (...
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Article
Open AccessMolecular assembly of rhodopsin with G protein-coupled receptor kinases
G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting ...
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Article
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways....
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Article
Crystal structure of mouse RhoA:GTPγS complex in a centered lattice
RhoA, a member of the Rho sub-family of small GTPases, plays a significant signaling role in cell morphogenesis, migration, neuronal development, cell division and adhesion. So far, 4 structures of RhoA:GDP/GT...
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Article
Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors
Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a wide spectrum of physiological activ...
