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Open AccessSocial distancing and extremely preterm births in the initial COVID-19 pandemic period
Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period.
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Open AccessUse of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in...
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Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years
Severe retinopathy of prematurity (ROP) is associated with adverse outcomes. Relationships between milder ROP and outcomes have not been defined. We hypothesized that children with ROP stage ≤3 who did not rec...
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Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm
Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that...
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Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial
This study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial.
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Blood myo-inositol concentrations in preterm and term infants
To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from...
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Neurodevelopmental outcomes at 2 years in term and late preterm newborns enrolled in a trial of hydrocortisone for cardiovascular insufficiency
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Neonatal oxygen saturations and blood pressure at school-age in children born extremely preterm: a cohort study
To explore the relationship between neonatal oxygen saturation and BP at age 6–7 years in a cohort of infants born extremely preterm.
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Optimizing antenatal corticosteroid therapy for improving outcome of premature infants
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Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm
Low birth weight in term-born individuals correlates with adverse cardiometabolic outcomes; excess glucocorticoid exposure has been linked to these relationships. We hypothesized that cortisol and adrenal andr...
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Neonatal outcomes of moderately preterm infants compared to extremely preterm infants
Extremely preterm infants (EPT, <29 weeks’ gestation) represent only 0.9% of births in the United States; yet these infants are the focus of most published research. Moderately preterm neonates (MPT, 29–336/7 wee...
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Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants
Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinet...
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Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23–29 wk
Myo-inositol given to preterm infants with respiratory distress has reduced death, increased survival without bronchopulmonary dysplasia, and reduced severe retinopathy of prematurity in two randomized trials. Ph...
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Open AccessAnalysis of neonatal clinical trials with twin births
In neonatal trials of pre-term or low-birth-weight infants, twins may represent 10–20% of the study sample. Mixed-effects models and generalized estimating equations are common approaches for handling correlat...
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Open AccessJoint distribution approaches to simultaneously quantifying benefit and risk
The benefit-risk ratio has been proposed to measure the tradeoff between benefits and risks of two therapies for a single binary measure of efficacy and a single adverse event. The ratio is calculated from the...
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Adrenal Insufficiency and Cardiac Dysfunction in the Preterm Infant
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Impaired Glucocorticoid Synthesis in Premature Infants Develo** Chronic Lung Disease
Premature infants have higher cortisol precursor concentrations than term infants; however, many sick preterm infants have surprisingly low cortisol concentrations. Those who develop chronic lung disease (CLD)...
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Lower Cortisol Concentrations in Premature Infants with Patent Ductus Arteriosus (PDA)
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Prophylaxis against Early Adrenal Insufficiency to Prevent Chronic Lung Disease in Premature Infants
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Impaired Glucocorticoid Synthesis in Preterm Infants Who Develop Chronic Lung Disease (CLD)