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Blood myo-inositol concentrations in preterm and term infants

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Abstract

Objective

To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age.

Design/Methods

Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values.

Results

In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants).

Conclusions

Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.

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Fig. 1: Cord myo-inositol concentration with prediction curves resulting linear regression models of natural log-transformed myo-inositol concentration with left censoring by gestational age at birth (weeks).
Fig. 2: Serial myo-inositol concentration with prediction curves resulting linear regression models of natural log-transformed myo-inositol concentration with left censoring by PMA (weeks) and feeding category (enterally fed, upper panel; NPO, lower panel).

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Data availability

Data reported in this paper may be requested through a data use agreement. Further details are available at https://neonatal.rti.org/index.cfm?fuseaction=DataRequest.Home.

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Acknowledgements

The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), through the Neonatal Research Network and the Pediatric Pharmacology Research Units Network, and the National Eye Institute provided grant support for the Inositol Cross-Sectional Blood study. The study was planned in 2004; recruitment was in 2005–2006. While NICHD staff did have input into the study design, conduct, analysis, and manuscript drafting, the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Data collected at participating sites of the NICHD Neonatal Research Network (NRN) were transmitted to RTI International, the data coordinating center (DCC) for the network, which stored, managed, and analyzed the data for this study. On behalf of the NRN, Dr. Abhik Das (DCC Principal Investigator) and Ms. Lisa Wrage (DCC Statistician) had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. The NICHD Pediatric Pharmacology Research Unit (PPRU) network provided support and advice in designing the PK study (JVA, JVDA, AAV, SEK, RMW), analyzing the data (SEK), and conducting the Inositol Assay (RDL): Jacob V. Aranda, MD PhD FRCPC, Wayne State University (U10 HD37261); John van der Anker, MD, Children’s National Medical Center (U10 HD45993); Steven E. Kern, PhD, College of Pharmacy, Robert M. Ward, MD, Department of Pediatrics, University of Utah Medical Center (U10 HD45986); Alexander A. Vinks, PharmD PhD FCP, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati (U10 HD37249); Richard D. Leff, PharmD FCCP, Texas Tech University Health Sciences Center, Pediatric Pharmacology Research & Development Center (U10 HD46000). We are indebted to our medical and nursing colleagues and the infants and their parents who took part in this study.

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Alan H. Jobe17, Michael S. Caplan18, Abbot R. Laptook19, Angelita M. Hensman19, Ronald N. Goldberg20, Kathy J. Auten20, Stephanie Wilson Archer21, James A. Lemons22, Dianne E. Herron22, Leslie Dawn Wilson22, W. Kenneth Poole23, Jeanette O’Donnell Auman23, Betty K. Hastings23, Norbert T. Kadima23, James W. PickettII23, Lisa A. Wrage23, Patricia Chess27, Linda J. Reubens27, Erica Burnell27, Mary Rowan27, Cassandra A. Horihan27, Nancy J. Peters28, Richard A. Ehrenkranz29, Patricia Gettner29, Monica Konstantino29, Joann Poulsen29, Janet Taft29.

Author information

Author notes

  1. Deceased: W. Kenneth Poole and Richard A. Ehrenkranz.

Authors and Affiliations

  1. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Luc P. Brion

  2. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

    Dale L. Phelps

  3. Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Robert M. Ward

  4. Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA

    Tracy L. Nolen, Daniel J. Zaccaro & Kristin M. Zaterka-Baxter

  5. PEDEGO Research Center, and MRC Oulu, University of Oulu, and Oulu University Hospital, Oulu, Finland

    N. Mikko K. Hallman

  6. Statistics and Epidemiology Unit, RTI International, Rockville, USA

    Abhik Das

  7. Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children’s Hospital, Palo Alto, CA, USA

    M. Bethany Ball & Krisa P. Van Meurs

  8. Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Kristi L. Watterberg

  9. Department of Pediatrics, Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA

    Ivan D. Frantz III

  10. Department of Pediatrics, Duke University, Durham, NC, USA

    C. Michael Cotten

  11. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

    Brenda B. Poindexter

  12. Department of Pediatrics, Women & Infants’ Hospital, Brown University, Providence, RI, USA

    William Oh

  13. Department of Pharmacy Practice, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA

    Ralph A. Lugo

  14. Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    T. Michael O’Shea

  15. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Rosemary D. Higgins

  16. College of Health and Human Services, George Mason University, Fairfax, VA, USA

    Rosemary D. Higgins

  17. University of Cincinnati, Cincinnati, OH, USA

    Alan H. Jobe

  18. Pritzker School of Medicine, University of Chicago, Chicago, IL, USA

    Michael S. Caplan

  19. Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island, Providence, RI, USA, (U10 HD27904)

    Abbot R. Laptook & Angelita M. Hensman

  20. Alamance Regional Medical Center, University Hospital, Duke University School of Medicine, and Durham Regional Hospital, Durham, NC, USA, (U10 HD40492, M01 RR30)

    Ronald N. Goldberg & Kathy J. Auten

  21. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA

    Stephanie Wilson Archer

  22. Riley Hospital for Children, Methodist Hospital, University Hospital, Indiana University, and Wishard Health Services, Bloomington, IN, USA, (U10 HD27856, M01 RR750)

    James A. Lemons, Dianne E. Herron & Leslie Dawn Wilson

  23. RTI International, Research Triangle Park, NC, USA, (U10 HD36790)

    W. Kenneth Poole, Jeanette O’Donnell Auman, Betty K. Hastings, Norbert T. Kadima, James W. Pickett II & Lisa A. Wrage

  24. Lucile Packard Children’s Hospital, Stanford University, Stanford, CA, USA, (U10 HD27880, M01 RR70)

    W. Kenneth Poole, Jeanette O’Donnell Auman, Betty K. Hastings, Norbert T. Kadima, James W. Pickett II & Lisa A. Wrage

  25. Tufts Medical Center, Floating Hospital for Children, Stanford, CA, USA, (U10 HD53119, M01 RR54)

    W. Kenneth Poole, Jeanette O’Donnell Auman, Betty K. Hastings, Norbert T. Kadima, James W. Pickett II & Lisa A. Wrage

  26. University of New Mexico Health Sciences Center, Albuquerque, NM, USA, (U10 HD53089, M01 RR997)

    W. Kenneth Poole, Jeanette O’Donnell Auman, Betty K. Hastings, Norbert T. Kadima, James W. Pickett II & Lisa A. Wrage

  27. Golisano Children’s Hospital, University of Rochester Medical Center, Rochester, NY, USA, (U10 HD40521, M01 RR44)

    Patricia Chess, Linda J. Reubens, Erica Burnell, Mary Rowan & Cassandra A. Horihan

  28. Brenner Children’s Hospital, Baptist Medical Center, Wake Forest University, and Forsyth Medical Center, Winston-Salem, NC, USA, (U10 HD40498, M01 RR7122)

    Nancy J. Peters

  29. Yale-New Haven Children’s Hospital, Yale University, New Haven, CT, USA, (U10 HD27871, UL1 RR24139, M01 RR125)

    Richard A. Ehrenkranz, Patricia Gettner, Monica Konstantino, Joann Poulsen & Janet Taft

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  1. Luc P. Brion
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Consortia

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

  • Alan H. Jobe
  • , Michael S. Caplan
  • , Abbot R. Laptook
  • , Angelita M. Hensman
  • , Ronald N. Goldberg
  • , Kathy J. Auten
  • , Stephanie Wilson Archer
  • , James A. Lemons
  • , Dianne E. Herron
  • , Leslie Dawn Wilson
  • , W. Kenneth Poole
  • , Jeanette O’Donnell Auman
  • , Betty K. Hastings
  • , Norbert T. Kadima
  • , James W. Pickett II
  • , Lisa A. Wrage
  • , Patricia Chess
  • , Linda J. Reubens
  • , Erica Burnell
  • , Mary Rowan
  • , Cassandra A. Horihan
  • , Nancy J. Peters
  • , Richard A. Ehrenkranz
  • , Patricia Gettner
  • , Monica Konstantino
  • , Joann Poulsen
  •  & Janet Taft

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Correspondence to Luc P. Brion.

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Members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network are listed below Acknowledgements.

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Brion, L.P., Phelps, D.L., Ward, R.M. et al. Blood myo-inositol concentrations in preterm and term infants. J Perinatol 41, 247–254 (2021). https://doi.org/10.1038/s41372-020-00799-5

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