12 Result(s)

Article

Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity, mortality and healthcare costs. Beta blockers are well-established drugs widely used to treat cardiovascular conditions. O...

Seonaidh Cotton, Graham Devereux, Hassan Abbas, Andrew Briggs, Karen Campbell… in Trials (2022)

Article

The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

Return of gastrointestinal (GI) function is fundamental to patient recovery after colorectal surgery and is required before patients can be discharged from hospital safely. Up to 40% of patients suffer delayed...

Hugh M. Paterson, Seonaidh Cotton, John Norrie, Susan Nimmo, Irwin Foo… in Trials (2022)

Article

Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): study protocol for a randomised controlled trial

Stress urinary incontinence (SUI) is a frequent adverse effect for men undergoing prostate surgery. A large proportion (around 8% after radical prostatectomy and 2% after transurethral resection of prostate (T...

Lynda Constable, Nikki Cotterill, David Cooper, Cathryn Glazener, Marcus J. Drake… in Trials (2018)

Article

HEALTH: laparoscopic supracervical hysterectomy versus second-generation endometrial ablation for the treatment of heavy menstrual bleeding: study protocol for a randomised controlled trial

Heavy menstrual bleeding (HMB) is a common problem affecting approximately 1.5 million women in England and Wales with a major impact on their physical, emotional, social and material quality of life. It is th...

Kevin Cooper, Kirsty McCormack, Suzanne Breeman, Jessica Wood, Neil W. Scott… in Trials (2018)

Article

THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial

Many adverse pregnancy outcomes in the UK could be prevented with better intrapartum care. Training for intrapartum emergencies has been widely recommended but there are conflicting data about their effectiven...

Erik Lenguerrand, Catherine Winter, Karen Innes… in BMC Pregnancy and Childbirth (2017)

Article

Overcoming a trial ‘adverse event’: impact and experiences of a temporary suspension of randomisation in clinical trials

Lynda Constable, Tracey Davidson, Samantha Wileman, Kirsty McCormack, Ruth Thomas… in Trials (2015)

Article

Trials recruiting patients in the acute NHS setting: trial management challenges

Seonaidh Cotton, Ruth Thomas, Sarah Cameron, Anne Duncan, Tracey Davidson… in Trials (2015)

Article

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present i...

Graham Devereux, Seonaidh Cotton, Peter Barnes, Andrew Briggs, Graham Burns… in Trials (2015)

Article

A pragmatic, multicentre, randomised controlled trial comparing stapled haemorrhoidopexy to traditional excisional surgery for haemorrhoidal disease (eTHoS): study protocol for a randomised controlled trial

Current interventions for haemorrhoidal disease include traditional haemorrhoidectomy (TH) and stapled haemorrhoidopexy (SH) surgery. However, uncertainty remains as to how they compare from a clinical, qualit...

Angus J M Watson, Hanne Bruhn, Kathleen MacLeod, Alison McDonald… in Trials (2014)

Article

Comparative study of new imaging technologies for the diagnosis of glaucoma: design and conduct of a multi-centre diagnostic accuracy study

Katie Banister, Jonathan Cook, Craig Ramsay, Jennifer Burr, Rodolfo Hernández… in Trials (2013)

Article

Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy - a randomised controlled trial

Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic sur...

Momin Malik, Kirsty McCormack, Zygmunt H Krukowski, Alison McDonald… in Trials (2012)

Article

The effectiveness of metal on metal hip resurfacing: a systematic review of the available evidence published before 2002

Conventional total hip replacement (THR) may be felt to carry too high a risk of failure over a patient's lifetime, especially in young people. There is increasing interest in metal on metal hip resurfacing ar...

Laura Wyness, Luke Vale, Kirsty McCormack, Adrian Grant… in BMC Health Services Research (2004)