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Article
Open AccessA pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery - the FOCCUS study
Fluid strategies may impact on patient outcomes in major elective surgery. We aimed to study the effectiveness and cost-effectiveness of pre-operative fluid loading in high-risk surgical patients undergoing ma...
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Article
Open AccessA pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol
Patients undergoing major elective or urgent surgery are at high risk of death or significant morbidity. Measures to reduce this morbidity and mortality include pre-operative optimisation and use of higher lev...
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Article
Laparoscopic surgery for colorectal cancer: safe and effective? – A systematic review
To determine the clinical effectiveness of laparoscopic and laparoscopically assisted surgery in comparison with open surgery for the treatment of colorectal cancer.
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Article
Open AccessThe effectiveness of metal on metal hip resurfacing: a systematic review of the available evidence published before 2002
Conventional total hip replacement (THR) may be felt to carry too high a risk of failure over a patient's lifetime, especially in young people. There is increasing interest in metal on metal hip resurfacing ar...
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Article
Open AccessResource use data by patient report or hospital records: Do they agree?
Economic evaluations alongside clinical trials are becoming increasingly common. Cost data are often collected through the use of postal questionnaires; however, the accuracy of this method is uncertain. We co...
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Article
Collaborative placebo-controlled trial of dexamethasone for neonatal Chronic lung disease: a 3 year follow-up
287 preterm babies from 31 European and North American centres who were oxygen-dependent aged 3 weeks or more were randomized to dexamethasone or placebo. Active treatment was associated with reduced time on a...
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Chapter and Conference Paper
Develo** a Register of Randomised Controlled Trials in Perinatal Medicine
Randomised controlled trials (RCTs) have special strengths for assessing medical practice; yet they are difficult to identify with currently available literature search techniques. The National Perinatal Epide...
