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Article
A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species
Feruloylated acylglycerols (FAGs) have recently garnered a lot of interest as water–oil-miscible ferulic acid derivatives. A novel FAG derivate, 1-feruloyl-3-hexadecanoylglycerol (1), was isolated from Wikstroemi...
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Article
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation
Macrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the “Shock and Kill” strategy. In the present study, the first chemica...
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Article
Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis
Two new flavonoid glycosides, 2′,4′-dihydroxydihydrochalcone-4-O-β-d-glucopyranoside (1) and medicarpin-3-O-β-d-apiofuranosyl (1 → 2)-β-d-glucopyranoside (2), together with 34 known flavonoids were isolated from ...
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Article
Open AccessCorrection to: Identification of β‑carboline and canthinone alkaloids as anti‑inflammatory agents but with different inhibitory profile on the expression of iNOS and COX‑2 in lipopolysaccharide‑activated RAW 264.7 macrophages
The article Identification of β‑carboline and canthinone alkaloids as anti‑inflammatory agents but with different inhibitory profile on the expression of iNOS and COX‑2 in lipopolysaccharide‑activated RAW 264....
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Open AccessIdentification of β-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages
A compound library, which consists of 75 natural β-carboline-type or canthinone-type alkaloids from Simaroubaceae plants and their chemical synthetic analogues, was screened for the anti-inflammatory activity ...
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Article
Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent
Oxidative stress due to the overproduction of reactive oxygen species plays an important role in the pathogenesis of various diseases. In the present study, we comprehensively evaluated the antioxidant activit...
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Article
Enhanced ultrasound-assisted enzymatic hydrolysis extraction of quinolizidine alkaloids from Sophora alopecuroides L. seeds
Quinolizidine alkaloids are the main bioactive components in Sophora alopecuroides L. This study reports a novel ultrasound-assisted enzymatic hydrolysis method for the extraction of these important alkaloids. Bo...
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Article
Euphorins A–H: bioactive diterpenoids from Euphorbia fischeriana
Phytochemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of 23 diterpenoids (1–23), which were classified into five subtypes, namely, ent-rosane (1–9), ent-abietane (10–16), ent
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Article
What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?
Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is ...
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Article
ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells
The discovery of new drugs that target cancer stem cells (CSCs) is a critical approach to overcome the major difficulties of the metastasis, chemotherapeutic resistance and recurrence for successful cancer the...
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Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen–glucose deprivation and reperfusion
Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neon...
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Open AccessInhibitory activities of selected Kampo formulations on human aldose reductase
Diabetes complications include various symptoms such as diabetic neuropathy and cognitive disorders. Aldose reductase (AR) is the rate-limiting enzyme of the polyol pathway and is one of the causal factors of ...
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Article
Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis
Protein tyrosine phosphatase 1B (PTP1B) is a non-transmembrane protein tyrosine phosphatase, and has received much attention as a molecular target for the treatment of insulin resistance diseases because of it...
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Open AccessEvaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents
Protein tyrosine phosphatase (PTP) 1B, a negative regulator of the insulin and leptin signaling pathways, is currently considered a promising target for the development of novel therapeutic approaches used to ...
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Article
Anxiolytic-like effect of Shigyakusan extract with low side effects in mice
Shigyakusan is a traditional Japanese herbal (Kampo) medicine used to treat inflammatory conditions such as cholecystitis and gastritis as well as psychiatric disorders. This study examined the anxiolytic-like...
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Article
Phenolic constituents from the stems of Acanthopanax senticosus
A new phenolic glycoside was isolated from the stems of Acanthopanax senticosus together with sixteen known compounds. The structure of the new compound was determined to be 2,6-dimethoxy-4-[(1E)-3,3-dimethoxy-1-...
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Article
Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica
A novel α-tetralonyl derivative, juglanone, was isolated from the fresh unripe fruits of Juglans mandshurica. Its structure was determined by spectroscopic analyses and from chemical evidence. Juglanone exhibited...
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Article
Clinical effectiveness of KSS formula, a traditional folk remedy for alcohol hangover symptoms
A formula (KSS formula) containing the pith of Citrus tangerine Hort. et Tanaka (Kitsuraku), the rhizome of Zingiber officinale (Shokyo), and brown sugar has been traditionally used in China for the treatment of ...
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Article
Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin: a new rosamicin analogue derived from engineered Micromonospora rosaria
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Article
A new angeloylated triterpenoid saponin from the husks of Xanthoceras sorbifolia Bunge
A new angeloylated oleanane-type triterpenoid saponin, sorbifoliaside (1), and a known saponin, xanifolia O54, were isolated from the husks of Xanthoceras sorbifolia Bunge. Their chemical structures were elucidat...
