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Article
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway
Parkin (PARK2) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates wi...
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Article
Surface-state controlled synthesis of hydrophobic and hydrophilic carbon dots
It is of great significance to synthesize carbon dots (CDs) with desirable hydrophilicity for the ever-growing application of CDs in different fields. In this study, the hydrophilic and hydrophobic CDs were fa...
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Article
Trend, driving factors, and temperature-humidity relationship of the extreme compound hot and humid events in South China
With global warming and frequent occurrence of extreme hot events, the accompanying heat stress, which is believed to be the combined effects of temperature and humidity on human health, is also expected to in...
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Article
Interannual variability of diurnal temperature range in CMIP6 projections and the connection with large-scale circulation
Diurnal temperature range (DTR), as a core indicator of the Earth system, exhibits obvious temporal and spatial variations, which is not entirely consistent over global. The historical simulation capabilities ...
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Article
Open AccessSpousal collaboration mediates the relation between self-rated health and depressive symptoms of Chinese older couples: an actor-partner interdependence approach
Dyadic co** resources have been considered a potential explanatory mechanism of spousal interdependence in health, but the mediation of spousal collaboration for the relationship between self-rated health an...
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Article
A shock flash breaking out of a dusty red supergiant
Shock-breakout emission is light that arises when a shockwave, generated by the core-collapse explosion of a massive star, passes through its outer envelope. Hitherto, the earliest detection of such a signal w...
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Article
Impacts of Roof/Ground Mitigation Strategies on Improving the Urban Thermal Environment and Human Comfort over the Yangtze River Delta, China
The combined effects of global warming and the urban heat islands exacerbate the risk of urban heat stress. It is crucial to implement effective cooling measures in urban areas to improve the comfort of the th...
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Article
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata
Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses...
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Chapter and Conference Paper
A Crushable Experimental Device for Simulating Soft Impact on Structures
To investigate collision accidents such as vehicles and vessels impacting on structures in the laboratory, this paper introduces a type of novel experimental equipment, which is a soft impactor consisting of o...
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Article
Ultra-fast response behavior of aluminum hydride (AlH3) in a quasi-detonation environment
Aluminum hydride (AlH3), as a potential new metal fuel, has attracted extensive attention in the field of hydrogen storage materials, propellants and energetic materials due to its excellent properties. In this p...
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Article
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function
Breast cancer is one of the major malignancies in women, and most related deaths are due to recurrence, drug resistance, and metastasis. The expression of the mouse double minute 2 (MDM2) oncogene is upregulat...
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Article
Open AccessNavigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997–2022)...
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Article
Open AccessA novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in triple negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive and malignant subtype in breast cancer. Immunotherapy is a currently promising and effective treatment for TNBC, while not all patients are responsiv...
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Article
Open AccessSingle-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more complex interactions between metastatic cancer cells and other...
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Article
Open AccessAlterations of the gut microbiota in patients with postherpetic neuralgia
Postherpetic neuralgia (PHN) is a prevalent, intricate, and intractable form of neuropathic pain. The available evidence indicates that alterations in the gut microbiota are significant environmental determina...
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Article
Open AccessHigh-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis
Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a complicated multistep process, which is determined by complex gen...
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Article
Open AccessElevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the **’an Stroke Registry Study of China
Few studies have explored the prognostic role of nontraditional lipid-related indicators in non-disabling ischemic cerebrovascular events (NICE). In this study, we aimed to investigate the relationship between...
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Article
Correction to: Real-world emission for in-use non-road construction machinery in Wuhan, China
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Article
Real-world emission for in-use non-road construction machinery in Wuhan, China
Non-road construction machinery (NRCM) emissions pollutants significantly impact air quality. Six typical NRCM (2 excavators, 3 loaders, and 1 forklift) are analyzed based on a portable emission measurement sy...
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Article
Open AccessMultidimensional evaluation of offline and online education in dermatology teaching during the COVID-19 pandemic in a chinese teaching hospital: a cross-sectional study
The global spread of Coronavirus disease (COVID-19) has led to the use of online teaching methods in universities, but the effect of online education on dermatology teaching remains unclear.
