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Article
CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation
Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfunction is an important part of this pathogenesis. Carnitine palmitoyltransferase (CPT1A)...
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Article
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
Chronic hepatitis B virus (HBV) infection is the primary risk factor for the malignant progression of hepatocellular carcinoma (HCC). It has been reported that HBV X protein (HBx) possesses oncogenic propertie...
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Article
Open AccessEpigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment
Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various malignancies. However, the role of LDHB in modulating immune responses ...
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Article
Prediction model for low bone mass mineral density in type 2 diabetes: an observational cross-sectional study
Considering the prevalence of type 2 diabetes (T2D), osteoporosis should be considered a serious complication. However, an effective tool for the assessment of low bone mass mineral density (BMD) in T2D patien...
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Article
Nodal s± pairing symmetry in an iron-based superconductor with only hole pockets
The origin of high-temperature superconductivity in iron-based superconductors is still not understood; determination of the pairing symmetry is essential for understanding the superconductivity mechanism. In ...
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Article
Transcriptomic and metabolomic analysis provides insight into imazethapyr toxicity to non-target plants
Imazethapyr is a widely used imidazolinone herbicide worldwide, and its potential adverse effects on non-target plants have raised concerns. Understanding the mechanisms of imazethapyr phytotoxicity is crucial...
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Article
Open AccessResearch on WSN reliable ranging and positioning algorithm for forest environment
Wireless sensor network (WSN) location is a significant research area. In complex environments like forests, inaccurate signal intensity ranging is a major challenge. To address this issue, this paper presents...
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Article
A novel MRC framework for evidence extracts in judgment documents
Evidences are important proofs to support judicial trials. Automatically extracting evidences from judgement documents can be used to assess the trial quality and support “Intelligent Court”. Current evidence ...
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Article
Design of home fitness assistant system based on android mobile network and optical sensing system
In recent years, the increase in health awareness has made fitness activities more and more popular in families. The lack of professional guidance and real-time feedback during home fitness training is often a...
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Article
Open AccessA Deep Convolutional Encoder–Decoder–Restorer Architecture for Image Deblurring
The accuracy of many computer vision tasks is reduced by blurred images, so deblur is important. More details of the image can be captured by a common multi-stage network, but the computational complexity of t...
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Article
CaMKIIδ, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP
Calcium/calmodulin-dependent protein kinase II (CaMKII) has been demonstrated to be aberrantly activated in viral myocarditis (VMC), but the role of its subtype CaMKIIδ in VMC remains unclear.
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Article
Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m5C sites ...
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Article
Open AccessCorrection: TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
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Article
Occurrence, ecological risk, and advanced removal methods of herbicides in waters: a timely review
Coastal pollution caused by the importation of agricultural herbicides is one of the main environmental problems that directly affect the coastal primary productivity and even the safety of human seafood. It i...
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Article
Open AccessA three-gene signature reveals changes in the tumor immune microenvironment in the progression from NAFLD to HCC
Hepatocellular carcinoma (HCC) is one of the most dangerous malignant tumors. The incidence rates of obesity related NAFLD and NASH are increasing year by year, and they are the main risk factors for HCC at pr...
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Article
Open AccessStructures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity
Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to ...
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Article
Open AccessRNA m6A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis
N6-methyladenosine (m6A), the most prevalent mRNA modification, has an important function in diverse biological processes. However, the involvement of m6A in allergic asthma and macrophage homeostasis remains lar...
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Article
The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke
Ischemic stroke is a major public health problem worldwide. Although the circadian clock is involved in the process of ischemic stroke, the exact mechanism of the circadian clock in regulating angiogenesis aft...
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Article
Reinforcing the mechanical properties of bamboo fiber/low density polyethylene composites with modified bamboo-woven structure
In order to improve the environmental problems caused by the extensive use of plastics, this paper introduced a new strategy to add and modify the physical structure, which could not only reduce the use of pla...
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Article
Recognition of Sand Bodies Based on Their Characteristics and Lithology
With the deepening of oil and gas exploration and development, the conventional seismic inversion technology has certain limitations for the fine research of complex reservoirs, and the actual production has h...
