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Article
Temporal dynamics and genomic programming of plasma cell fates
Affinity-matured plasma cells (PCs) of varying lifespans are generated through a germinal center (GC) response. The developmental dynamics and genomic programs of antigen-specific PC precursors remain to be el...
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Article
ThPOK is a critical multifaceted regulator of myeloid lineage development
The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and critical role of ThPOK as a multiface...
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Article
Brain motor and fear circuits regulate leukocytes during acute stress
The nervous and immune systems are intricately linked1. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remai...
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Article
Open AccessGain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies
Mutations in the cardiac splicing factor RBM20 lead to malignant dilated cardiomyopathy (DCM). To understand the mechanism of RBM20-associated DCM, we engineered isogenic iPSCs with DCM-associated missense mut...
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Article
Open AccessSingle-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
While the majority of cells contain a single nucleus, cell types such as trophoblasts, osteoclasts, and skeletal myofibers require multinucleation. One advantage of multinucleation can be the assignment of dis...
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Article
Open AccessPublisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Mouse models of neutropenia reveal progenitor-stage-specific defects
Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular ...
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Article
Open AccessMBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemia have remained elusive and clinical outcomes remain dismal. MBNL1, a protein involved ...
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Article
Open AccessDefining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a powerful tool for human disease modeling and therapeutic testing. However, their use remains limited by their immaturity and...
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Article
Open AccessDefective transcription elongation in a subset of cancers confers immunotherapy resistance
The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion of cancers have widespread defects in mRNA transcription elongation (TE). Canc...
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Article
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors ...
