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Article
Open AccessFOXQ1 promotes pancreatic cancer cell proliferation, tumor stemness, invasion and metastasis through regulation of LDHA-mediated aerobic glycolysis
Pancreatic cancer (PC), a gastrointestinal tract malignant tumor, has a poor prognosis due to early metastasis and limited response to chemotherapy. Therefore, identifying novel therapeutic approaches for PC i...
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Article
Open AccessExpression of Myomaker and Myomerger in myofibers causes muscle pathology
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two muscle-specific fusogens, Myomaker and Myomerg...
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Article
Open AccessArthroscopically assisted versus open reduction internal fixation for ankle fractures: a systematic review and meta-analysis
Open reduction and internal fixation were routinely used to treat patients with unstable ankle fractures (ORIF). However, some patients may experience persistent ankle pain and disability following ORIF due to...
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Article
Open AccessRHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway
Pancreatic cancer (PC) is one of the most malignant types of cancer, and is characterized by early metastasis, limited response to chemotherapeutics, and poor prognosis. Therefore, there is an urgent need to e...
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Article
Lisfranc injuries with dislocation the first tarsometatarsal joint: primary arthrodesis or internal fixation (a randomized controlled trial)
Open reduction and internal fixation (ORIF) is a popular method for treatment of displaced Lisfranc injuries. However, even with anatomic reduction and solid internal fixation, treatment does not provide good ...
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Article
Open AccessFOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis
Although FOXD1 has been found to be involved in the malignant processes of several types of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to investigate the expression an...
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Article
A comprehensive study of volatile organic compounds from the actual emission of Chinese cooking
China’s current perspective for big cities was filled with great population, great number of restaurants, growing gaseous pollutants, and great pollution. Volatile organic compounds (VOCs) were the main compon...
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Article
Open AccessHypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis
Accumulating evidence has demonstrated the essential role of long noncoding RNAs (lncRNAs) in various types of human cancer, including pancreatic cancer (PC). However, the functions and regulatory mechanisms o...
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Article
Open AccessProdigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
Prodigiosin (PG), a natural red pigment produced by numerous bacterial species, has been a eye-catching research point in recent years for its anticancer activity. However, the role of PG in the cancer biology...
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Article
Open AccessFibroblast fusion to the muscle fiber regulates myotendinous junction formation
Vertebrate muscles and tendons are derived from distinct embryonic origins yet they must interact in order to facilitate muscle contraction and body movements. How robust muscle tendon junctions (MTJs) form to...
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Article
Open AccessSingle-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
While the majority of cells contain a single nucleus, cell types such as trophoblasts, osteoclasts, and skeletal myofibers require multinucleation. One advantage of multinucleation can be the assignment of dis...
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Article
Open AccessLncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis
Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...
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Article
Open AccessMicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12
Cancer stem cells (CSCs) play an important role in the development of pancreatic cancer. We previously showed that the microRNA miR-137 is downregulated in clinical samples of pancreatic cancer, and its expres...
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Article
miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2
The morbidity and mortality of hepatocellular carcinoma (HCC) is very high, finding new therapeutic targets are critical for HCC treatment. miR-522 has been demonstrated to be upregulated in HCC tissues, but i...
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Article
TRIM37 promoted the growth and migration of the pancreatic cancer cells
Increasing evidence indicated that tripartite motif containing 37 (TRIM37) was involved in the tumorigenesis of several cancer types. However, its expression pattern and biological functions in pancreatic duct...
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Article
Open AccessMicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1
The prognosis of pancreatic cancer ranks among the worst of all cancer types, which is primarily due to the fact that during the past decades little progress has been made in its diagnosis and treatment. Here,...
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Article
MicroRNA-100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3
We intended to investigate the role of microRNA 100 (miR-100) in regulating pancreatic cancer cells’ growth in vitro and tumor development in vivo. QTR-PCR was used to examine the expression of miR-100 in panc...
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Article
Open AccessMicroRNA-492 expression promotes the progression of hepatic cancer by targeting PTEN
Aberrant microRNA (miRNA) expression plays an essential role in the pathogenesis of Hepatocellular Carcinoma (HCC). However, specific involvement of miRNAs in HCC remains incompletely understood. The aim of th...
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Article
Cosmological evolution of quintessence with a sign-changing interaction in dark sector
Dark energy and dark matter are only indirectly measured though their gravitational effects. It is possibie that there is some direct, non-gravitational interaction between DE and DM, which can be used to solv...
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Chapter and Conference Paper
Studying the Effect of the Group-Size on the Search Computing Cost of MEC for Function Optimization
Mind evolutionary computation (MEC) is an approach of evolution computation that was proposed in 1998 by Chengyi Sun. The search computing cost which is affected obviously by the group size is an important mea...
