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Article
Open AccessThe best linear unbiased prediction (BLUP) method as a tool to estimate the lifetime risk of pancreatic ductal adenocarcinoma in high-risk individuals with no known pathogenic germline variants
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the Western world. The number of diagnosed cases and the mortality rate are almost equal as the majority of patien...
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Article
Open AccessThe Spanish Familial Pancreatic Cancer Registry (PANGENFAM): a decade follow-up of individuals at high-risk for pancreatic cancer
The Spanish Familial Pancreatic Cancer Registry (PANGENFAM) was established in 2009 and aims to characterize the genotype and phenotype of familial pancreatic cancer (FPC). Furthermore, an early detection scre...
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Chapter
Giant Macrophages: Characteristics and Clinical Relevance
Tumor cell dissemination is mediated by a subpopulation of cells referred to as circulating tumor cells (CTCs), which have epithelial to mesenchymal properties and an inherent capacity to intravasate from the ...
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Article
Open AccessISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSC...
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Article
Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance
Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infi...
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Article
Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’
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Open AccessDifferential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer
Exosome production from cancer-associated fibroblasts seems to be an important driver of tumor progression. We report the first in-depth biotype characterization of ncRNAs, analyzed by Next Generation Sequenci...
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Article
Open AccessErratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
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Article
Mosaic loss of chromosome Y is associated with common variation near TCL1A
Meredith Yeager, Stephen Chanock and colleagues analyze mosaic loss of the Y chromosome in three prospective cohorts and observe association with age and smoking but not with cancer survival. They also identif...
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Article
Open AccessErratum to: The UBC-40 Urothelial Bladder Cancer Cell Line Index: a genomic resource for functional studies
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Open AccessCirculating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer
Pancreatic cancer remains one of the most difficult cancers to treat with the poorest prognosis. The key to improving survival rates in this disease is early detection and monitoring of disseminated and residu...
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Article
Open AccessThe UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
Urothelial bladder cancer is a highly heterogeneous disease. Cancer cell lines are useful tools for its study. This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lin...
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Article
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy
Francisco Real and colleagues report exome sequencing in urothelial bladder tumors. They show that STAG2, a subunit of the cohesin complex, is recurrently mutated and provide evidence that STAG2 loss does not lea...
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Protocol
Single-Nucleotide Polymorphism (SNP) Analysis to Associate Cancer Risk
Identification of hereditary factors that predispose to cancer allows targeted cancer screening and better quantification of environmental risk factors. The ability to identify which single nucleotide polymorp...
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Article
Development of Temporal Temperature Gradient Electrophoresis for Characterising Methanogen Diversity
Temporal temperature gradient electrophoretic (TTGE) analysis of 16S rDNA sequences was optimized to monitor the methanogen population present in water and sediments of a small eutrophic lake, Priest Pot, in t...
