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Article
Open AccessInhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness and resilience against chemotherapy is the existence of cancer stem cells...
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Article
Open AccessEffects of self-regulated learning and procrastination on academic stress, subjective well-being, and academic achievement in secondary education
The main objective of this study was to test a structural theoretical model of the effects of self-regulated learning on academic stress, subjective well-being, and academic achievement in Secondary Education,...
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Article
Open AccessMeasurement Invariance of the Brief Resilient Co** Scale (BRCS) in Peruvian and Spanish Older Adults
Although the Brief Resilient Co** Scale (BRCS) has been validated in some European and American countries, there are no studies that evaluate its factorial invariance among different nations. In this sense, ...
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Article
Open AccessExploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells
Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a 5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is believed to be due to the exis...
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Article
Perceived Social Support, School Adaptation and Adolescents’ Subjective Well-Being
Positive psychology has promoted well-being research in adolescents. However, there is not enough research about the determinants of well-being at school. Specifically, the determinants of academic performance...
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Article
Open AccessISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSC...
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Article
Open AccessCancer associated fibroblast FAK regulates malignant cell metabolism
Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism...
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Article
Open AccessHallmarks of cancer stem cell metabolism
Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production o...
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Article
Dimensionality and Validation of the Dispositional Hope Scale in a Spanish Sample
Hope has emerged as a central construct when discussing human psychological strengths, well-being and quality of life. The first and most used instrument presented to measure the construct was the dispositiona...
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Article
Validating the Portuguese Version of the Satisfaction With Life Scale in an Elderly Sample
Life satisfaction is referred to a cognitive, judgmental process (Diener et al. in J Pers Assess 49:71–75, 1985), in which person’s quality of life is globally assessed according to his/her chosen criteria (Shin ...
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The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis
Liver fibrosis is the final consequence of many chronic liver injuries that later develop in cirrhosis and hepatocellular carcinoma (HCC), which are leading causes of morbidity and mortality worldwide. The tra...
