Mucosal Delivery of Biopharmaceuticals
Biology, Challenges and Strategies
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Article
Nanoscale anisotropy for biomedical applications
Nanoparticles exhibit anisotropy when distinct features can be identified along different axes. Such disruption in shape and/or composition symmetry can change how nanoparticles behave and interact with the su...
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Article
Encapsulation and release of hydrocortisone from proliposomes govern vaginal delivery
Topical preparations of hydrocortisone can be used for the anti-inflammatory treatment of the female genital area. Although the drug is a low-strength corticosteroid, systemic absorption and distribution of th...
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Article
Open AccessMap** age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018
Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to m...
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Article
Bioactive Protein Hydrolysate Obtained from Canned Sardine and Brewing By-products: Impact of Gastrointestinal Digestion and Transepithelial Absorption
A sardine protein hydrolysate (SPH) was prepared by hydrolysis of sarcoplasmic proteins from canned sardine by-product with proteases from brewer’s spent yeast (BSY). The SPH presented in vitro angiotensin con...
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Protocol
Production and Characterization of Anti-CCR5 siRNA-Loaded Polycaprolactone Nanoparticles for Topical Pre-exposure Prophylaxis
Topical posttranscriptional silencing of host factors involved in HIV-1 sexual transmission, such as CCR5, presents the potential to prevent new cases of infection. However, issues concerning proper engineerin...
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Article
Open AccessThe solid progress of nanomedicine
This commentary article conveys the views of the board of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society regarding the decision of the United States National Cancer Insti...
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Article
Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol
The clinical translation of the multiple pharmacological effects of resveratrol (RSV) found in preclinical studies has been impaired by its poor bioavailability, due to poor solubility and rapid metabolism and...
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Article
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
An amendment to this paper has been published and can be accessed via a link at the top of the paper
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Article
On the issue of transparency and reproducibility in nanomedicine
Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.
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Article
Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice
To assess the potential of polymeric nanoparticles (NPs) to affect the genital distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug candidate dapivirine after vaginal deli...
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Book
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Chapter
Vaginal Delivery of Biopharmaceuticals
The vagina may be an interesting alternative route for the delivery of biopharmaceuticals, particularly for the management of local conditions or the prevention of infection. The field of anti-HIV microbicides...
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Article
Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine
To assess the intracellular delivery, antiretroviral activity and cytotoxicity of poly(ε-caprolactone) (PCL) nanoparticles containing the antiretroviral drug dapivirine.
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Protocol
Preparation of Polyelectrolyte Nanocomplexes Containing Recombinant Human Hepatocyte Growth Factor as Potential Oral Carriers for Liver Regeneration
The large number of cytokines and growth factors implicated in the regulation of liver regeneration has led to the possibility of using these molecules in therapy, namely, in the case of recombinant human hepa...
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Article
Foamability of Detergent Solutions Prepared with Different Types of Surfactants and Waters
In the development of new detergent products, it is important to test the foaming behavior of different types of surfactants. Different types and concentrations of surfactant solutions prepared with three type...
