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Article
Nanoscale anisotropy for biomedical applications
Nanoparticles exhibit anisotropy when distinct features can be identified along different axes. Such disruption in shape and/or composition symmetry can change how nanoparticles behave and interact with the su...
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Chapter
Microfluidic Technologies for Precise Drug Delivery
There is a current demand for new and more sophisticated drug delivery systems (DDSs) to efficiently deliver therapeutics to the desired tissues, enhance drug formulations, and enable industrial-scale producti...
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Article
Open AccessZein nanoparticles as oral carrier for mometasone furoate delivery
Mometasone furoate (MF) is a synthetic glucocorticoid used clinically to treat specific inflammatory disorders including superior and inferior respiratory tract. Due to its poor bioavailability we further inve...
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Article
Open AccessscFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells
Colorectal cancer (CRC) is one of the deadliest cancers worldwide, with the 5 year survival rate in metastatic cases limited to 12%. The design of targeted and effective therapeutics remains a major unmet clin...
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Article
Open AccessFunctionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides
Peptides have a distinguished therapeutic potential for several chronic conditions, and more than 80 peptides exist in the global market. However, most of these marketed peptide drugs are currently delivered i...
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Article
CRS Local chapters special issue 2023
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Article
Multifunctional nanomedicine strategies to manage brain diseases
Brain diseases represent a substantial social and economic burden, currently affecting one in six individuals worldwide. Brain research has been focus of great attention in order to unravel the pathogenesis an...
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Article
Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults. This type of cancer is characterized by a high mortality rate, especially for patients with resistant lung metastases. Giv...
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Protocol
Cell Interplay Model to Assess the Impact of Glioma Cells on Blood–Brain Barrier Permeability
The blood–brain barrier (BBB) is the most selective protecting layer of the central nervous system (CNS) with unique neurovascular features. The BBB is known to undergo a process of molecular alterations durin...
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Article
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier
Search for efficient therapeutic agents for central nervous system (CNS) disorders has been extensive. Nevertheless, blood–brain barrier (BBB) is an obstacle that prevents the majority of compounds to act in t...
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Living Reference Work Entry In depth
Cell-Based Intestinal In Vitro Models for Drug Absorption Screening
Despite major innovations in drug administration, oral intake remains the preferred route for drug delivery, mainly due to ease of administration and high patient compliance. Therefore, intestinal permeability...
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Article
Open AccessPseudoboehmite as a drug delivery system for acyclovir
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent ...
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Article
Open AccessCorrection to: A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin
A correction to this paper has been published: https://doi.org/10.1007/s13346-021-00957-y
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Article
Open AccessA nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin
The potential of nanoemulsions for the oral administration of peptides is still in its early stage. The aim of the present work was to rationally design, develop, and fully characterize a new nanoemulsion (NE)...
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Article
Open AccessAntagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic
Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic s...
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Protocol
Production and Characterization of Anti-CCR5 siRNA-Loaded Polycaprolactone Nanoparticles for Topical Pre-exposure Prophylaxis
Topical posttranscriptional silencing of host factors involved in HIV-1 sexual transmission, such as CCR5, presents the potential to prevent new cases of infection. However, issues concerning proper engineerin...
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Chapter
Chitosan Polymeric Micelles as Oral Delivery Platform of Hydrophobic Anticancer Drugs
Oral drug administration is the most common and preferred route of administration for both patients and doctors. However, some drugs, as the case of hydrophobic anticancer drugs, cannot be administered orally ...
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Chapter
In Vitro Assays for Nanoparticle—Cancer Cell Interaction Studies
Nanotechnology is a rapid-growing field with an extreme potential to revolutionize cancer treatments. However, despite the rapid advances, the clinical translation is still scarce. One of the main hurdles cont...
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Article
Emerging trends in nano- and microencapsulation science: hallmarks of the 22nd International Symposium on Microencapsulation
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Article
Increasing levels of insulin secretion in bioartificial pancreas technology: co-encapsulation of beta cells and nanoparticles containing GLP-1 in alginate hydrogels
The success of diabetes treatment with bioartificial pancreas is still hindered by a high rate of graft failure caused by poorly functioning cells. The incretin effect of glucagon like peptide-1 (GLP-1) make t...
