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  1. No Access

    Article

    Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

    In the biosynthesis of many macrocyclic natural products by multidomain megasynthases, a carboxy-terminal thioesterase (TE) domain is involved in cyclization and product release1,2; however, it has not been deter...

    John W. Trauger, Rahul M. Kohli, Henning D. Mootz, Mohamed A. Marahiel… in Nature (2000)

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    Regulation of gene expression by small molecules

    Small molecules that target specific DNA sequences have the potential to control gene expression. Ligands designed for therapeutic application must bind any predetermined DNA sequence with high affinity and pe...

    Joel M. Gottesfeld, Laura Neely, John W. Trauger, Eldon E. Baird, Peter B. Dervan in Nature (1997)

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    Recognition of DNA by designed ligands at subnanomolar concentrations

    SMALL molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have b...

    John W. Trauger, Eldon E. Baird, Peter B. Dervan in Nature (1996)