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  1. No Access

    Article

    Structural basis for G•C recognition in the DNA minor groove

    Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole–imidazole polyamides represent the only class of synthetic small molecules...

    Clara L. Kielkopf, Eldon E. Baird, Peter B. Dervan… in Nature Structural Biology (1998)

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    Article

    Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

    The design of synthetic ligands that read the information stored in the DNA double helix has been a long-standing goal at the interface of chemistry and biology1,2,3,4,5. Cell-permeable small molecules that targe...

    Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan in Nature (1998)

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    Article

    Regulation of gene expression by small molecules

    Small molecules that target specific DNA sequences have the potential to control gene expression. Ligands designed for therapeutic application must bind any predetermined DNA sequence with high affinity and pe...

    Joel M. Gottesfeld, Laura Neely, John W. Trauger, Eldon E. Baird, Peter B. Dervan in Nature (1997)

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    Article

    Recognition of DNA by designed ligands at subnanomolar concentrations

    SMALL molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have b...

    John W. Trauger, Eldon E. Baird, Peter B. Dervan in Nature (1996)

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    Article

    Faster rates with less catalyst in template-directed reactions

    We have recently shown that the polycytidylic acid-directed polymerization of guanosine 5′-monophosphate 2-methylimidazolide (2-McImpG) is amenable to kinetic study and that rate determinations as a function o...

    Anastassia Kanavarioti, Eldon E. Baird in Journal of Molecular Evolution (1995)

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    Article

    Affinity of guanosine derivatives for polycytidylate revisited

    Evidence is presented for complexation of guanosine 5′-monophosphate 2-methylimidazolide (2-MeImpG) with polycytidylate (poly(C)) at pH 8.0 and 23°C in the presence of 1.0 M NaCl and 0.2 M MgCl2 in water. The ass...

    Anastassia Kanavarioti, T. Brian Hurley, Eldon E. Baird in Journal of Molecular Evolution (1995)