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  1. No Access

    Article

    Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

    T cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Cav1.4-β3 channels are needed for the survival and homeostasis of naive CD8+ T cells.

    Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory… in Nature Immunology (2009)

  2. No Access

    Article

    ORL1 receptor–mediated internalization of N-type calcium channels

    The inhibition of N-type calcium channels by opioid receptor like receptor 1 (ORL1) is a key mechanism for controlling the transmission of nociceptive signals. We recently reported that signaling complexes con...

    Christophe Altier, Houman Khosravani, Rhian M Evans, Shahid Hameed… in Nature Neuroscience (2006)

  3. No Access

    Chapter

    Molecular Properties of Voltage-Gated Calcium Channels

    Terrance P. Snutch, Jean Peloquin, Eleanor Mathews… in Voltage-Gated Calcium Channels (2005)

  4. No Access

    Article

    Agonist-independent modulation of N-type calcium channels by ORL1 receptors

    We have investigated modulation of voltage-gated calcium channels by nociceptin (ORL1) receptors. In rat DRG neurons and in tsA-201 cells, nociceptin mediated a pronounced inhibition of N-type calcium channels...

    Aaron M Beedle, John E McRory, Olivier Poirot, Clinton J Doering… in Nature Neuroscience (2004)

  5. No Access

    Article

    P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A

    Spatial and temporal changes in intracellular calcium concentrations are critical for controlling gene expression in neurons1,2,3,4,5. In many neurons, activity-dependent calcium influx through L-type channels st...

    Kathy G. Sutton, John E. McRory, Heather Guthrie, Timothy H. Murphy… in Nature (1999)