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Article
Open AccessDeep behavioural phenoty** of the Q175 Huntington disease mouse model: effects of age, sex, and weight
Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of th...
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Article
Open AccessMesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning
Understanding the basis of brain function requires knowledge of cortical operations over wide spatial scales and the quantitative analysis of brain activity in well-defined brain regions. Matching an anatomica...
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Article
A three-dimensional virtual mouse generates synthetic training data for behavioral analysis
We developed a three-dimensional (3D) synthetic animated mouse based on computed tomography scans that is actuated using animation and semirandom, joint-constrained movements to generate synthetic behavioral d...
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Article
Open AccessPiDose: an open-source system for accurate and automated oral drug administration to group-housed mice
Drug treatment studies in laboratory mice typically employ manual administration methods such as injection or gavage, which can be time-consuming to perform over long periods and cause substantial stress in an...
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Article
Open AccessStress impacts sensory variability through cortical sensory activity motifs
Medically unexplained symptoms in depression are common. These individual-specific complaints are often considered an ‘idiom of distress’, yet animal studies suggest that cortical sensory representations are f...
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Article
Open AccessPeripheral Nerve Ligation Elicits Widespread Alterations in Cortical Sensory Evoked and Spontaneous Activity
Peripheral neuropathies result in adaptation in primary sensory and other regions of cortex, and provide a framework for understanding the localized and widespread adaptations that arise from altered sensation...
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Article
Open AccessHigh-throughput automated home-cage mesoscopic functional imaging of mouse cortex
Mouse head-fixed behaviour coupled with functional imaging has become a powerful technique in rodent systems neuroscience. However, training mice can be time consuming and is potentially stressful for animals....
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Article
Open AccessReal-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
It has become well accepted that Huntington disease (HD) is associated with impaired glutamate uptake, resulting in a prolonged time-course of extracellular glutamate that contributes to excitotoxicity. Howeve...
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Article
Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs
Neuroimaging of spontaneous, resting-state infraslow (<0.1 Hz) brain activity has been used to reveal the regional functional organization of the brain and may lead to the identification of novel biomarkers of...
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Article
Open AccessA dynamic model for delta rhythm fit to high-frequency cortical activity data shows discrete functional connectivity in mouse cortex
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Article
Spontaneous cortical activity alternates between motifs defined by regional axonal projections
Using voltage sensitive–dye imaging in the cortices of anesthetized and awake mice, the authors show that spontaneous activity patterns contain similar motifs as those evoked by sensory stimulation. These moti...
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Article
Open AccessA model for delta rhythm fit to high-frequency cortical activity data
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Article
Plasticity during stroke recovery: from synapse to behaviour
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and impairment of sensatio...
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Article
Automated light-based map** of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice
Optical stimulation of channelrhodopsin-2 expressed in neurons of the motor cortex is combined with electromyogram recordings or motion-sensing of limb muscles to achieve fast motor map** in the mouse.
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Article
Activity-dependent synapse development: changing the rules
In a recent Nature paper, reduction of postsynaptic activity within single neurons of an active network reveals a new role for Hebbian competition during early development.
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Article
Differential regulation of synaptic and extra-synaptic NMDA receptors
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application1,2,3,
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Article
P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A
Spatial and temporal changes in intracellular calcium concentrations are critical for controlling gene expression in neurons1,2,3,4,5. In many neurons, activity-dependent calcium influx through L-type channels st...
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Chapter and Conference Paper
Phosphoinositide-Linked Glutamate Receptors: Prominent Actions in Neurons and Glia
Recent studies have identified a novel glutamate receptor subtype that is coupled to activation of the phosphoinositide (PI) cycle [1–6]. To help identify the role of this receptor in mediating effects of exci...
