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Article
Oncolytic mineralized bacteria as potent locally administered immunotherapeutics
Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of inactivated bacteria is poor, and attenuated live bacteria pose substantial safety risks. Here we show that intratumou...
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Article
Open AccessPneumonic-type lung adenocarcinoma with KRAS G12V mutation and sustained response to Afatinib
Pneumonic-type lung adenocarcinoma (P-ADC) is a rare and challenging subtype of primary lung cancer that can be difficult to distinguish from pneumonia based on radiological images. Furthermore, no drugs are c...
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Article
Learnable scene prior for point cloud semantic segmentation
In this paper, we propose a Geo-SceneEncoder framework to handle point cloud scene semantic segmentation, including a SceneEncoder to learn a scene prior, an advanced geometric kernel to learn geometry informa...
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Article
Synergy of ZnO Nanowire Arrays and Electrospun Membrane Gradient Wrinkles in Piezoresistive Materials for Wide-Sensing Range and High-Sensitivity Flexible Pressure Sensor
Flexible pressure sensors have come under the spotlight because of their widespread adoption in human motion detection and human‒machine interactions. However, manufacturing pressure sensors with broad sensing...
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Article
Open AccessAssessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy
Despite the central role of human leukocyte antigen class I (HLA-I) in tumor neoantigen presentation, quantitative determination of presentation capacity remains elusive. Based on a pooled pan-cancer genomic d...
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Article
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes
Prolonged stimulation of β-adrenergic receptor (β-AR) can lead to sympathetic overactivity that causes pathologic cardiac hypertrophy and fibrosis, ultimately resulting in heart failure. Recent studies suggest...
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Chapter and Conference Paper
Where to Turn: Road Fork Detection in Sparse 3D Point Cloud
Intersection detection plays a crucial role in localizing and planning the path of autonomous vehicles in urban environments. This paper presents a novel approach, PVWO, for adaptive intersection detection in ...
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Chapter and Conference Paper
Leveraging Panoptic Prior for 3D Zero-Shot Semantic Understanding Within Language Embedded Radiance Fields
Language Embedded Radiance Fields (LERF) achieves promising results in real-time dense relevancy maps within NeRF 3D scenes. Although LERF shows impressive zero-shot ability in many long-tail open-vocabulary q...
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Article
Spatial–temporal distribution characteristics of pollutants of heavy-duty diesel vehicles in urban road networks: a case study of Kunming City
With the continuous promotion of urbanization in China, the economic level of small and medium-sized cities has been further improved. The transportation industry is crucial in promoting urban–rural integratio...
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Article
HSNet: hierarchical semantics network for scene parsing
Scene parsing is one of the fundamental tasks in computer vision. Humans tend to perceive a scene in a hierarchical manner, i.e., first identifying the coarse category (e.g., vehicle) of a group of objects and...
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Article
Open AccessGenetic trajectory and clonal evolution of multiple primary lung cancer with lymph node metastasis
Multiple primary lung cancer (MPLC) with lymph node metastasis (LNM) is a rare phenomenon of multifocal lung cancer. The genomic landscapes of MPLC and the clonal evolution pattern between primary lung lesions...
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Article
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions
With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are co...
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Article
Open AccessOptimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors
Although immune checkpoint inhibitors (ICIs) have influenced the treatment paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive resistance may limit the long-term efficacy...
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Article
Open AccessSingle-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer
Small-cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer, for which, better understandings of its biology are urgently needed. Single-cell sequencing technologies provide an oppor...
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Article
Open AccessMolecular profiling of human non-small cell lung cancer by single-cell RNA-seq
Lung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance and failure. Single-cell RNA sequencing (scRNA-s...
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Article
Open AccessMET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review
Numerous therapeutic agents specifically targeting the mesenchymal-epithelial transition (MET) oncogene are being developed.
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Chapter and Conference Paper
Optimization over Disentangled Encoding: Unsupervised Cross-Domain Point Cloud Completion via Occlusion Factor Manipulation
Recently, studies considering domain gaps in shape completion attracted more attention, due to the undesirable performance of supervised methods on real scans. They only noticed the gap in input scans, but ign...
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Chapter and Conference Paper
Self-supervised Compressed Video Action Recognition via Temporal-Consistent Sampling
Compressed video action recognition targets at classifying action class in compressed video, instead of decoded/standard video. It benefits from fast training and inference by reducing the utilization of redun...
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Chapter and Conference Paper
Compound Figure Separation of Biomedical Images with Side Loss
Unsupervised learning algorithms (e.g., self-supervised learning, auto-encoder, contrastive learning) allow deep learning models to learn effective image representations from large-scale unlabeled data. In med...
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Article
Open AccessIntegrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here, we perform multi-omics analysis of 56 PSC samples, 14 of which are microdissected to analyze intratumoral heter...
