12 Result(s)

Article

Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR

Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse cl...

Seongjae Kim, Jung Min Park, Soeun Park… in Journal of Experimental & Clinical Cancer … (2023)

Article

A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response

Despite recent advances, there remains a significant unmet need for the development of new targeted therapies for triple-negative breast cancer (TNBC). Although the heat shock protein HSP90 is a promising targ...

Ji Young Kim, Tae-Min Cho, Jung Min Park, Soeun Park, Minsu Park, Kee Dal Nam… in Oncogene (2022)

Article

Correction to: Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin

Se-Kyeong Jang, Sung-Eun Hong, Da-Hee Lee, Ji-Young Kim, Ji Yea Kim… in BMC Cancer (2021)

Article

Secondhand smoke exposure, diabetes, and high BMI are risk factors for uterine cervical cancer: a cross-sectional study from the Korea national health and nutrition examination survey (2010–2018)

Human papilloma virus infection and tobacco smoking are the major risk factors for cervical cancer. There are limited studies searching other risk factors for cervical cancer and the results are not consistent...

Ji Young Kim, Dae Woo Lee, Min Jeong Kim, Jae Eun Shin, Yeun Joo Shin… in BMC Cancer (2021)

Article

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin

Although the major anticancer effect of metformin involves AMPK-dependent or AMPK-independent mTORC1 inhibition, the mechanisms of action are still not fully understood.

Se-Kyeong Jang, Sung-Eun Hong, Da-Hee Lee, Ji-Young Kim, Ji Yea Kim… in BMC Cancer (2021)

Article

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer

Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little s...

Jung Min Park, Yoon-Jae Kim, Soeun Park, Minsu Park, Lee Farrand… in Molecular Cancer (2020)

Article

KSNM/KSID/KOSHIC Guidance for Nuclear Medicine Department Against the Coronavirus Disease 2019 (COVID-19) Pandemic

The dramatic spread of Coronavirus Disease 2019 (COVID-19) has profound impacts on every continent and life. Due to human-to-human transmission of COVID-19, nuclear medicine staffs also cannot escape the risk ...

Ji-In Bang, Ho-Young Lee, Young Seok Cho… in Nuclear Medicine and Molecular Imaging (2020)

Article

Comparison of diagnostic sensitivity of [¹⁸F]fluoroestradiol and [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography for breast cancer recurrence in patients with a history of estrogen receptor-positive primary breast cancer

To compare the diagnostic sensitivity of [¹⁸F]fluoroestradiol ([¹⁸F]FES) and [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) for breast cancer recurrence in patients w...

Sun Young Chae, Hye Joo Son, Dong Yun Lee, Eonwoo Shin, Jungsu S. Oh… in EJNMMI Research (2020)

Article

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...

So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi… in Journal of Experimental & Clinical Cancer … (2019)

Article

A phase 1, first-in-human study of ¹⁸F-GP1 positron emission tomography for imaging acute arterial thrombosis

¹⁸F-GP1 is a novel positron emission tomography (PET) tracer that targets glycoprotein IIb/IIIa receptors on activated platelets. The study objective was to explore the feasibility of directly imaging acute arte....

Sun Young Chae, Tae-Won Kwon, Soyoung **, Sun U. Kwon, Changhwan Sung… in EJNMMI Research (2019)

Article

Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers

The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and re...

Nadine Tung, Alexander Miron, Stuart J Schnitt, Shiva Gautam… in Breast Cancer Research (2010)

Article

Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

To investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.

Seung-Gu Yeo, Juree Kim, Geum-Hee Kwak, Ji-Young Kim, Kyeongmee Park… in Radiation Oncology (2010)