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Article
Open AccessSuppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse cl...
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Article
Deciphering Functional Connectivity Differences Between Motor Imagery and Execution of Target-Oriented Gras**
This study aimed to delineate overlap** and distinctive functional connectivity in visual motor imagery, kinesthetic motor imagery, and motor execution of target-oriented gras** action of the right hand. F...
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Article
Open AccessEbastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase
We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of breast cancer stem cell (BCSC)-suppression in triple-negative...
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Article
Open Accessβ-Escin overcomes trastuzumab resistance in HER2-positive breast cancer by targeting cancer stem-like features
The emergence of de novo or intrinsic trastuzumab resistance is exceedingly high in breast cancer that is HER2 positive and correlates with an abundant cancer stem cell (CSC)-like population. We sought to exam...
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Article
Open AccessA novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response
Despite recent advances, there remains a significant unmet need for the development of new targeted therapies for triple-negative breast cancer (TNBC). Although the heat shock protein HSP90 is a promising targ...
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Article
Open AccessThe C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-t...
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Article
Effects of Automatic Abdominal Massage Device in Treatment of Chronic Constipation Patients: A Prospective Study
Manual abdominal massage has been shown to effectively treat slow-transit constipation, but it is labor-intensive. To offer an alternative treatment option for constipation, the Bamk-001 automatic abdominal ma...
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Article
Open AccessNew polyp image classification technique using transfer learning of network-in-network structure in endoscopic images
While colorectal cancer is known to occur in the gastrointestinal tract. It is the third most common form of cancer of 27 major types of cancer in South Korea and worldwide. Colorectal polyps are known to incr...
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Article
Open AccessA novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer
Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little s...
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Article
Effect of work-related factors on the prevalence of peptic ulcer disease among Korean workers: a nationwide population-based study
Working environment such as psychosocial factors impacts the health of workers. However, few studies have assessed the association of work-related factors with the prevalence of peptic ulcer disease (PUD) in l...
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Article
Open AccessApplication of tylosin antibiotics to olive flounder (Paralichthys olivaceus) infected with Streptococcus parauberis
Olive flounder, Paralichthys olivaceus, is an economically important aquaculture species in Korea. Olive flounders have been heavily damaged by streptococcal infections every year and are treated with antibiotics...
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Article
Open AccessHER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer
Human epidermal growth factor receptor 2 (HER2) is implicated in several cancers, including gastric cancer. However, limited data are available regarding its clinical significance in early gastric cancer (EGC)...
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Article
Virtual Reality-based Control of Robotic Endoscope in Laparoscopic Surgery
Robotic laparoscopic surgery has provided various benefits, but during the surgery, the surgeons are experiencing uncomfortable positioning issue which leads to neck pain and back pain. So, for an enhanced & e...
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Article
Manufacturing and Control of a Robotic Device for Time-averaged Simulated Micro and Partial Gravity of a Cell Culture Environment
Gravity is omnipresent for all objects on Earth. However, in an environment of different gravitational stress (e.g., microgravity or partial gravity), cells and organs show different biological responses. So, ...
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Article
Spotting malignancies from gastric endoscopic images using deep learning
Gastric cancer is a common kind of malignancies, with yearly occurrences exceeding one million worldwide in 2017. Typically, ulcerous and cancerous tissues develop abnormal morphologies through courses of prog...
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Article
Development of an Automatic Instrument for Efficient Measuring the Joint’s Range of Motion
A range of motion (ROM) has been measured using several indices to judge the progress of ankylosing spondylitis (AS). However, measuring and calculating the ROM is time-consuming & labor-intensive and it would...
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Article
Comparison of outcomes of continuation/discontinuation of 5-aminosalicylic acid after initiation of anti-tumor necrosis factor-alpha therapy in patients with inflammatory bowel disease
Few maintenance therapeutic options are available for inflammatory bowel disease (IBD). Data on the effects of continuing 5-aminosalicylic acid (5-ASA) treatment in patients who commence on biologics as mainte...
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Article
Open AccessTarget-oriented motor imagery for gras** action: different characteristics of brain activation between kinesthetic and visual imagery
Motor imagery (MI) for target-oriented movements, which is a basis for functional activities of daily living, can be more appropriate than non-target-oriented MI as tasks to promote motor recovery or brain-com...
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Article
Open AccessCircadian rhythm disruption is associated with an increased risk of sarcopenia: a nationwide population-based study in Korea
Reduced sleep quality is associated with an increased risk of sarcopenia. However, the potential effects of disturbing the regular circadian rhythm, as occurs with shift work, on the risk of sarcopenia have no...
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Article
Autologous blood, a novel agent for preoperative colonic localization: a safety and efficacy comparison study
Preoperative localization is essential for minimally invasive colorectal surgery. However, conventional endoscopic tattooing agents such as India ink have safety issues. The availability of new endoscopic mark...
