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Article
Open AccessPTK2 is a potential biomarker and therapeutic target for EGFR- or TLRs-induced lung cancer progression via the regulation of the cross-talk between EGFR- and TLRs-mediated signals
Protein tyrosine kinase 2 (PTK2), epidermal growth factor receptor (EGFR), and toll-like receptor (TLRs) are amplified in non-small cell lung cancer (NSCLC). However, the functional and clinical associations b...
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Article
Simultaneous detection of residues of 34 beta-lactam antibiotics in livestock and fish samples through liquid chromatography-tandem mass spectrometry
β-Lactam is one of the widely used veterinary drugs, but simultaneous analytical methods for β-lactam on various animal foods have not been established. In this study, we aimed to detect 34 β-lactam antibiotics s...
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Article
Sex-specific differences in ectopic fat and metabolic characteristics of paediatric nonalcoholic fatty liver disease
Sex-specific differences in obesity-related metabolic characteristics of non-alcoholic fatty liver disease (NAFLD) have rarely been explored, particularly in children with biopsy-verified NAFLD. The influence ...
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Article
Open AccessInvestigation of safety and efficacy of febantel and fenbendazole in fish and exposure assessment
Fish are susceptible to blood-sucking parasite infections, which cause severe anemia, dyspnea, and ultimately death. However, veterinary drugs available for fish to treat such infectious diseases are lacking; ...
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Article
Comparison of Acquisition Criteria Applied to Individual and Sets of Tacts: A Systematic Replication
The experimenters examined two different levels of acquisition criteria—Set and Operant Analysis—to assess acquisition and response maintenance of tact operants for four participants. Set Analysis involved rep...
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Article
Open AccessThickness of melanocytes in giant congenital melanocytic nevus for complete surgical excision: clinicopathological evaluation of 117 lesions according to the area and size
Giant congenital melanocytic nevi (GCMN) are usually defined as nevi that exceed 20 cm in maximal diameter or 15% of the total body surface area. There have been reports of life-long malignant change risks ari...
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Article
Analysis of Shear Characteristics of Quenchable Boron-Alloyed Steel 22MnB5 During the Hot Mechanical Piercing Process
Hot stam** is a widely adopted technique for manufacturing high-strength vehicle body parts using boron-alloyed steels, such as 22MnB5. This process involves heating the material to 900 ℃ or higher in a furn...
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Article
Delayed Consequences in General Education through the Lenses of Delay Discounting and Verbal Behavior
Delayed consequences have important academic implications for younger children. Conceptualized within behavior analysis as delay discounting, researchers have examined verbal behavior interventions to improve ...
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Article
Open AccessSimultaneous determination of 31 Sulfonamide residues in various livestock matrices using liquid chromatography-tandem mass spectrometry
The widespread use of sulfonamides can result in the residue of sulfonamides in the foods of animal origin that are the major concerns of consumers and regulatory bodies due to their adverse reaction such as t...
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Article
Open AccessRe-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
As veterinary drugs available for fish is very restricted, there is growing trials for repurposing livestock drugs as aquatic animal drugs. Tylosin is one of the most effective antibiotics to treat bacterial i...
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Article
Validation of a Method Based on Liquid Chromatography-Tandem Mass Spectrometry for Multiclass Screening and Analysis of 59 Veterinary Drugs in Fishery Foods
Veterinary drugs (VDs) are regulated to prevent their abuse or misuse and protect humans that consume animal-based food products from exposure to VD residues. VD residues are managed according to the maximum r...
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Article
Open AccessThe added value of SPECT/CT lymphoscintigraphy in the initial assessment of secondary extremity lymphedema patients
An added value of SPECT/CT over planar lymphoscintigraphy for initial staging in patients with secondary extremity lymphedema was investigated. Furthermore, we developed a hybrid SPECT/CT classification combin...
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Article
Open AccessSuppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse cl...
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Article
Open AccessAngiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disease that results in bone ankylosis. The tissue renin-angiotensin system (RAS) is an emerging pathway potentially implicated in SpA-associated bone changes....
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Article
Open AccessThe clinical effectiveness of fused image of single-photon emission CT and facial CT for the evaluation of degenerative change of mandibular condylar head
The primary objective of this study was to assess the clinical effectiveness of fused images obtained from single-photon emission computed tomography (SPECT) and facial computed tomography (CT) for evaluating ...
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Article
Open AccessAspacochioside C from Asparagus cochinchinensis attenuates eumelanin synthesis via inhibition of TRP2 expression
Aspacochioside C (ACC) is a steroidal saponin isolated from Asparagus cochinchinensis. Steroidal saponins, such as pseudoprotodioscin and dioscin, are known to inhibit melanogenesis, but the role of ACC in melano...
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Article
Inhibition of the NLRP3 Inflammasome Activation/Assembly through the Activation of the PI3K Pathway by Naloxone Protects Neural Stem Cells from Ischemic Condition
Naloxone is a well-known opioid antagonist and has been suggested to have neuroprotective effects in cerebral ischemia. We investigated whether naloxone exhibits anti-inflammatory and neuroprotective effects i...
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Article
Open AccessBarcoded multiple displacement amplification for high coverage sequencing in spatial genomics
Determining mutational landscapes in a spatial context is essential for understanding genetically heterogeneous cell microniches. Current approaches, such as Multiple Displacement Amplification (MDA), offer hi...
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Article
Open Accessβ‐arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-κB activation and autophagy induced by TLR3 and TLR4
β‐arrestin 2 (ARRB2) is functionally implicated in cancer progression via various signaling pathways. However, its role in lung cancer remains unclear. To obtain clinical insight on its function in lung cancer...
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Article
Comparison of the cytotoxicity of bisphenol A and its analogs on human placental BeWo cells
Bisphenol A (BPA) and its alternatives (BPF, BPS) are widely used in daily consumer products, which commonly expose humans to these chemicals. Bisphenols (BPs) are endocrine-disrupting chemicals widely present...
