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Open AccessLaboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-m...
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Article
Open AccessDistinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on...
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Article
Open AccessPulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
The severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investig...
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Article
Open AccessCorrelation between structural heart disease and cardiac SARS-CoV-2 manifestations
The prognosis of COVID-19 patients with cardiac involvement is unfavorable and it remains unknown which patients are at risk. The virus enters cells via its receptor angiotensin-converting enzyme 2 (ACE2). Myo...
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Article
Open AccessSarcoid-like lesions obfuscating the diagnosis of disseminated Mycobacterium genavense infection in a patient with IL-12Rβ1-associated immunodeficiency
Sarcoidosis is a systemic inflammatory disease that is characterized by non-caseating epithelioid-cell granulomas upon histology. However, similar histological findings may also be seen with certain infections...
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Studying severe long COVID to understand post-infectious disorders beyond COVID-19
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Open AccessFactors associated with impaired quality of life three months after being diagnosed with COVID-19
To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental and physical subcategories 3 months after diagnosis with COVID-19.
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Article
Open AccessQuantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019 (COVID-19). We extensively evaluated 145 COVID-19 patients at 3 fo...
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Article
Open AccessConsensus-Statement der Österreichischen Gesellschaften für Pneumologie und Rheumatologie zur Definition, Evaluation und Therapie von progredient fibrosierenden interstitiellen Lungenerkrankungen (pfILD)
Interstitielle Lungenerkrankungen (ILD) sind eine heterogene Gruppe von Pathologien, die zunehmend als relevanter Faktor pulmonaler Morbidität und Mortalität erkannt werden. Verschiedene ILD wie die idiopathis...
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Article
Open AccessOvercoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and ...
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Article
Open AccessDefining a therapeutic range for regeneration of ischemic myocardium via shock waves
Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at thera...
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Article
Open AccessPersisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study
Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmet...
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Article
Open AccessAnaemia, iron homeostasis and pulmonary hypertension: a review
Anaemia is a highly prevalent condition, which negatively impacts on patients’ cardiovascular performance and quality of life. Anaemia is mainly caused by disturbances of iron homeostasis. While absolute iron ...
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Article
Open AccessDietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by...
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Article
Open AccessThe impact of bacteremia on lipoprotein concentrations and patient’s outcome: a retrospective analysis
Bacteremia is a major clinical challenge requiring early treatment. Metabolic alterations occur during bacteremia, and accordingly plasma concentrations of lipoproteins LDL-C and HDL-C are substantially change...
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Article
Open AccessWhom to screen? A view on lung cancer screening from the pneumologist’s perspective
The benefits of screening programs are highly dependent on risk group definition. This is especially true for lung cancer screening. Results from the National Lung Cancer Screening Trial (NLST) and the NELSON ...
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Thyroid Hormones and Lipid Metabolism: Thyromimetics as Anti-Atherosclerotic Agents?
Overt hypothyroidism most often causes moderately elevated cholesterol and triglycerides; but, in genetically predisposed individuals, it can also trigger frank hyperlipidemia, e.g. type III hyperlipoproteinem...
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Article
Open AccessThe novel angiogenic cytokine secretoneurin promotes angiogenesis, arteriogenesis and vasculogenesis in the mouse hind-limb ischemia model
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Article
The K121Q polymorphism of ENPP1 and peripheral arterial disease
The K121Q variant of the ectonucleotide pyrophosphatase/ phosphodiesterase 1 (ENPP1) gene is associated with obesity, insulin resistance, and early myocardial infarction. Therefore, we hypothesized that the K1...
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Article
Hepatic ENPP1 expression is induced in diabetic rabbits
The ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an inhibitor of the insulin receptor. Variants of ENPP1 are associated with infantile arterial calcification, obesity, and insulin resistance. ...
