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Protocol
Identifying Cell Differentiation in Colorectal Cancer
The intestinal epithelium is a rapid self-renewing tissue. Stem cells at the bottom of the crypts first give rise to a proliferative progeny that finally differentiates to a variety of cell types. These termin...
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Protocol
A Label Retaining System to Capture Slow-Cycling Cancer Cells
Dormant or tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. Slow-cycling cancer cells (SCCC) represent a cellul...
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Article
Open AccessA caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we s...
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Article
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through concurrent modulation of cell adhesion and motility pr...
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Article
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognos...
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Article
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
Expression of Snail transcriptional factor is a determinant in the acquisition of a mesenchymal phenotype by epithelial tumor cells. However, the regulation of the transcription of this gene is still unknown. ...
