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Article
Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia
Acute myelocytic leukemia seriously impairs the health and lifespan of patients; thus, effective treatment methods for acute myelocytic leukemia need to be urgently determined. This study aimed to investigate ...
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Article
Urate-lowering agents do not have clinically relevant negative effects on sperm quality and reproductive hormones in men with gout: a prospective open-label cohort study
The objective of this study was to analyze and compare the effects of different urate-lowering agents on testicular functions in men with gout in a clinical setting.
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Article
Gold nanomaterials: important vectors in biosensing of breast cancer biomarkers
Breast cancer (BC) is one of the most common malignant tumors in women worldwide, and its incidence is increasing every year. Early diagnosis and treatment are critical to improve the curability and prognosis ...
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Article
Open AccessMiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice
Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for incre...
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Article
Open AccessExploring the impact of acute viral exposure on clinical characteristics and antibody profiles in antiphospholipid syndrome: a study in CAPSTONE
The relationship between antiphospholipid syndrome (APS) and acute viral infection, such as SARS-CoV-2, is unclear. This study aims to assess symptoms, antiphospholipid antibody (aPL) fluctuations, and complic...
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Article
Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation
Deep tissue infections caused by pathogenic bacteria seriously threat the lives of patients. In this study, a smart heterostructured Au/Cu–BTA (BTA = 1,2,4,5-benzenetetramine) with microwave (MW) response is s...
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Article
Open AccessCRISPR/Cas9-based genome-wide screening for metastasis ability identifies FCGR1A regulating the metastatic process of ovarian cancer by targeting LSP1
Metastasis is a main cause of death from ovarian cancer (OC). Identifying key markers involved in OC metastasis can aid in the effective detection of early postoperative metastasis. However, the role of FCGR1A...
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Article
Open AccessSingle-nucleus chromatin landscape dataset of mouse brain development and aging
The development and aging of the brain constitute a lifelong dynamic process, marked by structural and functional changes that entail highly coordinated cellular differentiation and epigenetic regulatory mecha...
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Article
Reply to: Phylogenomic and comparative genomic analyses support a single evolutionary origin of flatfish asymmetry
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Article
LncRNA ENST00000440246.1 Promotes Alzheimer’s Disease Progression by Targeting PP2A
Alzheimer’s disease (AD) is an extremely prevalent neurodegenerative disease. Long noncoding RNAs (lncRNAs) play pivotal roles in the regulation of AD. However, the function of most lncRNAs in AD remains to be...
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Article
Association between cardiometabolic index and erectile dysfunction among US adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 2001-2004
The aim of this study was to assess the association between a new metabolic index, the cardiometabolic index (CMI) and erectile dysfunction (ED). The data for this study relied on the National Health and Nutri...
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Article
Warmth or competence? Understanding voice shop** intentions from Human-AI interaction perspective
As increasing merchants launched AI chatbots based voice shop**, how to lead customers to embrace the emerging voice shop** channel is a key issue raised by many merchants. Despite considerable researchers...
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Article
Mixed Feelings About Supervisors: The Effect of LMX Ambivalence on Supervisor-Directed Behaviors
Integrating norms of reciprocity, affect theory of social exchange, and ambivalence literature, we investigated how leader-member exchange (LMX) ambivalence influences employees’ interpersonal behaviors toward...
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Article
Driving factors of residential demand response for the integration of variable renewable power
The large-scale integration of renewable power poses great challenges to grid stability. Among flexible resources, demand response (DR) stands out for its advantages in cost and efficiency. To identify key fac...
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Article
Open AccessHome-Visiting Programming in Kindergarten-Readiness Interventions: Retention and Loss of Families
Home-visiting programs are an often-used intervention for supporting the well-being of families with young children, and there is long-standing interest among researchers in ensuring the effectiveness of this ...
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Article
Open AccessDecitabine as epigenetic priming with CLAG induce improved outcome of relapsed or refractory acute myeloid leukemia in children
Decitabine (DAC), a DNA methyltransferase inhibitor, has shown efficacy combined with chemotherapy for relapsed or refractory (R/R) acute myeloid leukemia (AML) in adults, but less is known about its efficacy ...
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Article
Moderate Deviations for Parameter Estimation in the Fractional Ornstein-Uhlenbeck Processes with Periodic Mean
In this paper, we study the asymptotic properties for the drift parameter estimators in the fractional Ornstein-Uhlenbeck process with periodic mean function and long range dependence. The Cremér-type moderate...
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Article
Open AccessSingle-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes
The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use ampli...
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Article
Open AccessImmunophenotype of lymphocytes and real-world outcome of COVID-19 infection in children with hematology and oncology
Patients with immunocompromise were suspected to encounter a high risk for severe coronavirus disease 2019 (COVID-19) infection on early period; however, data is lacking nowadays and immune response remain unc...
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Article
Open AccessThe clinical value of mNGS of bronchoalveolar lavage fluid versus traditional microbiological tests for pathogen identification and prognosis of severe pneumonia (NT-BALF):study protocol for a prospective multi-center randomized clinical trial
Early, rapid, and accurate pathogen diagnosis can help clinicians select targeted treatment options, thus improving prognosis and reducing mortality rates of severe pneumonia. Metagenomic next-generation seque...
