Skip to main content

4 Result(s)

within Alexander N. Gorelick Remove this filter

and

  1. Article

    Open Access

    Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes

    The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use ampli...

    Minsoo Kim, Alexander N. Gorelick, Ignacio Vàzquez-García… in Nature Genetics (2024)

    Download PDF (13684 KB) View Article

  2. Article

    Open Access

    AKT mutant allele-specific activation dictates pharmacologic sensitivities

    AKT- a key molecular regulator of PI-3K signaling pathway, is somatically mutated in diverse solid cancer types, and aberrant AKT activation promotes altered cancer cell growth, survival, and metabolism1–8. The m...

    Tripti Shrestha Bhattarai, Tambudzai Shamu, Alexander N. Gorelick… in Nature Communications (2022)

    Download PDF (1770 KB) View Article

  3. No Access

    Article

    Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA

    Mitochondrial DNA (mtDNA) encodes protein subunits and translational machinery required for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data, in the present study we demonstrate...

    Alexander N. Gorelick, Minsoo Kim, Walid K. Chatila, Konnor La… in Nature Metabolism (2021)

  4. No Access

    Article

    Phase and context shape the function of composite oncogenic mutations

    Cancers develop as a result of driver mutations1,2 that lead to clonal outgrowth and the evolution of disease3,4. The discovery and functional characterization of individual driver mutations are central aims of c...

    Alexander N. Gorelick, Francisco J. Sánchez-Rivera, Yanyan Cai, Craig M. Bielski… in Nature (2020)