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Article
Benchmarking PathCLIP for Pathology Image Analysis
Accurate image classification and retrieval are of importance for clinical diagnosis and treatment decision-making. The recent contrastive language-image pre-training (CLIP) model has shown remarkable proficie...
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Article
Skin-on-a-Chip Coupled with a Rapid Inflammation Detection System for Cosmetic Ingredient Screening
The skin is the largest organ in the human body, and the physical and chemical factors from which human skin suffers make the human body prone to allergic and inflammatory reactions. The animal testing that ha...
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Article
Clustering single-cell RNA sequencing data via iterative smoothing and self-supervised discriminative embedding
Single-cell transcriptome sequencing (scRNA-seq) is a high-throughput technique used to study gene expression at the single-cell level. Clustering analysis is a commonly used method in scRNA-seq data analysis,...
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Article
Effects of fuel and driving conditions on particle number emissions of China-VI gasoline vehicles: based on corrections to test results
The increasing number of vehicles are emitting a large amount of particles into the atmosphere, causing serious harm to the ecological environment and human health. This study conducted the Worldwide Harmonize...
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Article
Open AccessDiagnostic implications of ubiquitination-related gene signatures in Alzheimer's disease
The purpose of this study was to explore the diagnostic implications of ubiquitination-related gene signatures in Alzheimer's disease. In this study, we first collected 161 samples from the GEO database (inclu...
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Article
Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation
SHP2 is a non-receptor protein tyrosine phosphatase to remove tyrosine phosphorylation. Functionally, SHP2 is an essential bridge to connect numerous oncogenic cell-signaling cascades including RAS-ERK, PI3K-A...
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Article
Open AccessEvidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review
Experiences during childhood and adolescence have enduring impacts on physical and mental well-being, overall quality of life, and socioeconomic status throughout one’s lifetime. This underscores the importanc...
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Article
Open AccessImpact of electronic cigarette usage on the onset of respiratory symptoms and COPD among Chinese adults
The prevalence of dual usage and the relatively low cessation rate among e-cigarette (EC) users suggest that ECs have not demonstrated significant effectiveness as a smoking cessation tool. Furthermore, there ...
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Article
Discovery and characterization of a new hydrothermal field at 2°N on the slow-spreading Carlsberg Ridge
A new hydrothermal field (Tianshi) was discovered on the rift valley wall through plume anomaly surveys and geological work conducted in 2012 and 2018 between 2°35′N and 2°43′N of the slow-spreading Carlsberg ...
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Article
Open AccessAnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding
Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail ...
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Article
Open AccessEPYC functions as a novel prognostic biomarker for pancreatic cancer
Pancreatic cancer (PC) has become a worldwide challenge attributed to its difficult early diagnosis and rapid progression. Treatments continue to be limited besides surgical resection. Hence, we aimed to disco...
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Article
In-Situ Precipitated Needle Like Nanocrystalline β-Ti Reinforced Porous Titanium Alloy via Molten Salt Electrolysis
Fabricating porous active metals through chemical dealloying poses challenges due to their reactivity and vulnerability to oxidation in aqueous solutions. The objective of this study was to create micron-sized...
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Article
MAF-Net: multidimensional attention fusion network for multichannel speech separation
Recent studies have shown that multichannel narrow-band speech separation achieves remarkable performance, while most successful deep learning-based studies directly work on the full-band spectrum of speech. M...
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Article
An adaptive dual-Kriging method based on parameter sensitivity analysis and application to vibration reduction optimization of helicopter rotor test-bed
The surrogate-based model optimization method has been successfully applied in various engineering optimization problems across multiple fields. However, when facing high-dimensional optimization problems with...
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Article
Open AccessHerbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
Huazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well e...
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Article
Fabrication of weaving structure copper tube for electromagnetic interference shielding material: effect of annealing temperature on its electromagnetic shielding performance
To design and fabricate a novel and low-cost electromagnetic interference shielding material with outstanding performance is becoming extremely popular by scientists over the years, owing to increasingly compl...
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Article
Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity
Monkeypox was declared a global health emergency by the World Health Organization, and as of March 2023, 86,000 confirmed cases and 111 deaths across 110 countries have been reported. Its causal agent, monkeyp...
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Article
Boosting the performance of deep-ultraviolet photodetector arrays based on phase-transformed heteroepitaxial β-Ga2O3 films for solar-blind imaging
Solar-blind imaging has attracted considerable interest in both military and civilian applications, spurring the development of high-performance deep-ultraviolet photodetector arrays (PDAs) with wide-bandgap s...
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Article
Open AccessMacrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery
Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribut...
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Article
State variable and optimization potential-based multi-objective optimization method and application in compressor blade airfoil design
To improve the optimization accuracy and efficiency, state variable and optimization potential-based multi-objective optimization (MOP) method is introduced. State variable records whether the simulation faile...
