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Article
Open AccessDCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway
Hepatocellular carcinoma (HCC) is a fatal malignancy with poor prognosis due to lack of effective clinical interference. DCAF1 plays a vital role in regulating cell growth and proliferation, and is involved in...
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Article
Open AccessDrug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer
Multi-modal combination therapy is regarded as a promising approach to cancer treatment. Combining chemotherapy and phototherapy is an essential multi-modal combination therapy endeavor. Ivermectin (IVM) is a ...
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Article
Open AccessCatalyst-free late-stage functionalization to assemble α-acyloxyenamide electrophiles for selectively profiling conserved lysine residues
Covalent probes coupled with chemical proteomics represent a powerful method for investigating small molecule and protein interactions. However, the creation of a reactive warhead within various ligands to for...
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Article
Population Pharmacokinetic/Pharmacodynamic Analysis of the Glucokinase Activator PB201 in Healthy Volunteers and Patients with Type 2 Diabetes Mellitus: Facilitating the Clinical Development of PB201 in China
PB201 is an orally active, partial glucokinase activator targeting both pancreatic and hepatic glucokinase. As the second glucokinase activator studied beyond phase I, PB201 has demonstrated promising glycemic...
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Article
Open AccessNeuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain, and GABA binding to the GABAA re...
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Article
Open AccessBLCA prognostic model creation and validation based on immune gene-metabolic gene combination
Bladder cancer (BLCA) is a prevalent urinary system malignancy. Understanding the interplay of immunological and metabolic genes in BLCA is crucial for prognosis and treatment.
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Article
Boosting the performance of deep-ultraviolet photodetector arrays based on phase-transformed heteroepitaxial β-Ga2O3 films for solar-blind imaging
Solar-blind imaging has attracted considerable interest in both military and civilian applications, spurring the development of high-performance deep-ultraviolet photodetector arrays (PDAs) with wide-bandgap s...
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Article
Open AccessExtracellular matrix stiffness aggravates urethral stricture through Igfbp3/Smad pathway
Urethral stricture refers to the narrowing of the urethral lumen. While previous studies have hinted at inflammation as the initial driver of this condition, the reasons and mechanisms behind its progression r...
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Article
Open AccessThe relationship between longer leukocyte telomeres and dNCR in non-cardiac surgery patients: a retrospective analysis
Cognitive decline following surgery is a common concern among elderly individuals. Leukocyte telomere length (LTL) can be assessed as a biological clock connected to an individual lifespan. However, the mechan...
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Article
Open AccessCorrection: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
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Article
Open AccessStudy of the mechanical characteristics of coal-serial sandstone after high temperature treatment under true triaxial loading
In this study, a series of true triaxial loading tests were carried out on coal-measure sandstone after high temperature treatment by using a self-developed true triaxial test system combined with acoustic emi...
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Article
Open AccessSLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis
Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was ...
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Article
Microstructures and Photovoltaic Properties of TiO2/BiFeO3 Core–Shell Nanowire Arrays
To address the current problem of low photoelectric conversion efficiency of BiFeO3 (BFO)-based photovoltaic (PV) devices, a TiO2/BFO core–shell nanowire array structure was constructed in this study based on the...
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Chapter and Conference Paper
A Gras** System with Structured Light 3D Machine Vision Guided Strategy Optimization
In scenarios such as automated sorting in logistics warehouses, automated assembly on industrial production lines, and transportation of rescue tasks and items, it is necessary to quickly grasp and place objec...
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Chapter and Conference Paper
Global-Aware Model-Free Self-distillation for Recommendation System
The recommendation performance in our Alipay advertising system may suffer from label noise in training data. Earlier approaches that relied on soft targets typically neglected global similarities. Here, we in...
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Article
Recognizing ideas generated in a creative thinking task: Effect of the subjective novelty
Prior studies have illustrated that a superior memory exists for self-access ideas compared with comprehension in close-ended problems. For example, an aha! experience followed by sudden solutions for insight pro...
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Article
Open AccessRescue of an enterotropic Newcastle disease virus strain ZM10 from cloned cDNA and stable expressing an inserted foreign gene
Newcastle disease virus (NDV) strain ZM10, a typical enterotropic avirulent vaccine strain, has been widely used in China for chickens against Newcastle disease. To elucidate its enterotropic mechanism and dev...
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Article
Comparing gratitude and pride: evidence from brain and behavior
Gratitude and pride are both positive emotions. Yet gratitude motivates people to help others and build up relationships, whereas pride motivates people to pursue achievements and build on self-esteem. Althoug...
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Article
Open AccessA toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria
Toxin EsaD secreted by some S. aureus strains through the type VII secretion system (T7SS) specifically kills those strains lacking the antitoxin EsaG. Here we report the structures of EsaG, the nuclease domain o...
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Article
Open AccessStudy on the role of SLC14A1 gene in biochemical recurrence of prostate cancer
Prostate cancer (PCa) is a common malignant disease among men and biochemical recurrence (BCR) is considered to be a decisive risk factor for clinical recurrence and PCa metastasis. Clarifying the genes relate...
