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Article
Open AccessDuration of effectiveness of the COVID-19 vaccine in Japan: a retrospective cohort study using large-scale population-based registry data
Most evidence of the waning of vaccine effectiveness is limited to a relatively short period after vaccination.
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Article
Open AccessAssociation between hospital palliative care team intervention volume and patient outcomes
The benefits of palliative care in patients with advanced cancer are well established. However, the effect of the skills of the palliative care team (PCT) on patient outcomes remains unclear. Our aim was to ev...
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Article
Relationship between proton pump inhibitor prescription and asthma exacerbation among adult patients: a self-controlled case series study
Proton-pump inhibitors (PPI) are empirically used to treat asthma symptoms such as cough; however, the effectiveness of PPI on asthma exacerbation has not been well studied. We aimed to evaluate the relationsh...
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Article
Body mass index and survival among patients with advanced biliary tract cancer: a single-institutional study with nationwide data-based validation
Excess body weight may modulate the progression of various cancer types. The prognostic relevance of body mass index (BMI) has not been fully examined in patients with biliary tract cancer.
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Article
Open AccessHospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation
Patients who receive invasive mechanical ventilation (IMV) in the intensive care unit (ICU) have exhibited lower in-hospital mortality rates than those who are treated outside. However, the patient-, hospital-...
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Article
“Association between perinatal mood disorders of parents and child health outcomes”
Perinatal mood disorders affect both parents, impacting their children negatively. Little is known on the association between parental perinatal mood disorders and pediatric outcomes in Japan considering relev...
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Article
Open AccessCost-effectiveness analysis of prophylactic laser peripheral iridotomy for primary angle-closure suspect in Japan
This study aimed to compare the cost-effectiveness of prophylactic laser peripheral iridotomy (LPI) with that of observation for primary angle-closure suspect (PACS) in Japan.
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Article
Open AccessA machine-learning-based prediction of non-home discharge among acute heart failure patients
Scarce data on factors related to discharge disposition in patients hospitalized for acute heart failure (AHF) were available, and we sought to develop a parsimonious and simple predictive model for non-home d...
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Article
Open AccessExploring the influence of a financial incentive scheme on early mobilization and rehabilitation in ICU patients: an interrupted time-series analysis
Clinical guidelines recommend early mobilization and rehabilitation (EMR) for patients who are critically ill. However, various barriers impede its implementation in real-world clinical settings. In 2018, the ...
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Article
Association between body mass index and outcomes after autologous breast reconstruction: a nationwide inpatient database study in Japan
Although autologous reconstruction following breast cancer surgery is common, little is known about the association between preoperative body mass index (BMI) and short-term surgical outcomes. This study inves...
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Article
Open AccessImpact of the COVID-19 pandemic on prehospital and in-hospital treatment and outcomes of patients after out-of-hospital cardiac arrest: a Japanese multicenter cohort study
In the chain of survival for Out-of-hospital cardiac arrest (OHCA), each component of care contributes to improve the prognosis of the patient with OHCA. The SARS-CoV-2 (COVID-19) pandemic potentially affected...
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Article
Association between aspirin dose and outcomes in patients with acute Kawasaki disease: a nationwide retrospective cohort study in Japan
This study aimed to identify the appropriate dose of aspirin to be prescribed to patients with acute Kawasaki disease (KD). Using a Japanese national inpatient database, we identified patients with KD treated ...
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Article
Nationwide epidemiology and clinical practice patterns of pediatric urinary tract infections: application of multivariate time-series clustering
The nationwide epidemiology and clinical practice patterns for younger children hospitalized with urinary tract infections (UTIs) were unclear.
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Article
Open AccessAssociated organs and system with COVID-19 death with information of organ support: a multicenter observational study
The organ dysfunction that is associated with death in COVID-19 patients has not been determined in multicenter epidemiologic studies. In this study, we evaluated the major association with death, concomitant ...
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Article
Open AccessTherapeutic plasma exchange for anti-glomerular basement membrane disease with dialysis-dependent kidney failure without diffuse alveolar hemorrhage
Anti-glomerular basement membrane (anti-GBM) disease is treated with immunosuppressive medications and plasma exchange. However, whether plasma exchange, in addition to pulse glucocorticoid therapy, would bene...
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Article
Risk factors for postoperative anastomotic leakage after repair of esophageal atresia: a retrospective nationwide database study
Postoperative anastomotic leakage is the most frequent short-term complication of esophageal atresia repair in neonates. We conducted this study using a nationwide surgical database in Japan to identify the ri...
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Article
Open AccessAssociation between lifestyle habits and glaucoma incidence: a retrospective cohort study
Although lifestyle habits may represent modifiable risk factors of glaucoma, the association between lifestyle factors and glaucoma is not well understood. The aim of this study was to investigate the associat...
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Article
Impact of Preoperative Stoma Site Marking on Morbidity and Mortality in Patients with Colorectal Perforation: A Nationwide Retrospective Cohort Study
Preoperative stoma site marking reduces the incidence of complications from elective surgery. However, the impact of stoma site marking in emergency patients with colorectal perforation remains unclear. This s...
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Article
Open AccessThrombotic risk of platinum combination chemotherapy with and without immune checkpoint inhibitors for advanced non-small cell lung cancer: a nationwide inpatient database study
To determine the associated thromboembolism risk with adding immune checkpoint inhibitors (ICI) to platinum combination chemotherapy compared with platinum combination chemotherapy alone in patients with advan...
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Article
Open AccessRisk factors for early mortality in elderly patients with unstable isolated C2 odontoid fracture treated with halo-vest or surgery
The aim of this study was to compare in-hospital mortality of three procedures –halo-vest immobilization, anterior spinal fixation (ASF), and posterior spinal fixation (PSF)– in the treatment of elderly patien...
