-
Article
Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population
Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different gene...
-
Article
Open AccessDuration of effectiveness of the COVID-19 vaccine in Japan: a retrospective cohort study using large-scale population-based registry data
Most evidence of the waning of vaccine effectiveness is limited to a relatively short period after vaccination.
-
Article
Body mass index and survival among patients with advanced biliary tract cancer: a single-institutional study with nationwide data-based validation
Excess body weight may modulate the progression of various cancer types. The prognostic relevance of body mass index (BMI) has not been fully examined in patients with biliary tract cancer.
-
Article
Open AccessA machine-learning-based prediction of non-home discharge among acute heart failure patients
Scarce data on factors related to discharge disposition in patients hospitalized for acute heart failure (AHF) were available, and we sought to develop a parsimonious and simple predictive model for non-home d...
-
Article
Association between aspirin dose and outcomes in patients with acute Kawasaki disease: a nationwide retrospective cohort study in Japan
This study aimed to identify the appropriate dose of aspirin to be prescribed to patients with acute Kawasaki disease (KD). Using a Japanese national inpatient database, we identified patients with KD treated ...
-
Article
Nationwide epidemiology and clinical practice patterns of pediatric urinary tract infections: application of multivariate time-series clustering
The nationwide epidemiology and clinical practice patterns for younger children hospitalized with urinary tract infections (UTIs) were unclear.
-
Article
Risk factors for postoperative anastomotic leakage after repair of esophageal atresia: a retrospective nationwide database study
Postoperative anastomotic leakage is the most frequent short-term complication of esophageal atresia repair in neonates. We conducted this study using a nationwide surgical database in Japan to identify the ri...
-
Article
Open AccessThrombotic risk of platinum combination chemotherapy with and without immune checkpoint inhibitors for advanced non-small cell lung cancer: a nationwide inpatient database study
To determine the associated thromboembolism risk with adding immune checkpoint inhibitors (ICI) to platinum combination chemotherapy compared with platinum combination chemotherapy alone in patients with advan...
-
Article
Open AccessRisk factors for early mortality in elderly patients with unstable isolated C2 odontoid fracture treated with halo-vest or surgery
The aim of this study was to compare in-hospital mortality of three procedures –halo-vest immobilization, anterior spinal fixation (ASF), and posterior spinal fixation (PSF)– in the treatment of elderly patien...
-
Article
Kampo medicine in ICUs in Japan between 2010 and 2020
-
Article
The association of BP with cardiovascular outcomes in patients with dipstick proteinuria and preserved kidney function
Little is known about the relationship between blood pressure (BP) and incident cardiovascular disease (CVD) in people with proteinuria and a preserved estimated glomerular filtration rate (eGFR). This study s...
-
Article
Open AccessDescriptive statistics and risk factor analysis of children with community-acquired septic shock
Children with community-acquired septic shock can rapidly deteriorate and die in acute-care hospitals. This study aimed to describe the mortality, timing, and risk factors in children with community-acquired s...
-
Article
Open AccessComparison of bleeding complications after pediatric kidney biopsy between intravenous sedation and general anesthesia: a nationwide cohort study
An increasing number of studies are evaluating the safety of intravenous sedation compared with that of general anesthesia; however, data on bleeding complications after pediatric percutaneous renal biopsy per...
-
Article
Risk factors for arm lymphedema following breast cancer surgery: a Japanese nationwide database study of 84,022 patients
Although arm lymphedema is a well-known complication following breast cancer surgery, previous studies involving a small population showed inconsistent results regarding the risk. Therefore, we examined the ri...
-
Article
Perioperative outcomes of laparoscopically assisted anorectoplasty versus conventional procedures for anorectal malformation: a retrospective nationwide database study
This study aimed to compare the perioperative outcomes of laparoscopically assisted anorectoplasty (LAARP) and conventional procedures (CPs) for anorectal malformation (ARM) using a national inpatient database...
-
Article
Association between intravenous immunoglobulin dose and outcomes in patients with acute Kawasaki disease
The most effective dosage of intravenous immunoglobulin (IVIG) to prevent coronary artery abnormalities (CAAs) in patients with acute Kawasaki disease (KD) remains unknown. This study aimed to identify the app...
-
Article
Open AccessMajor complications after percutaneous biopsy of native or transplanted liver in pediatric patients: a nationwide inpatient database study in Japan
Although major complication rates following percutaneous liver biopsy (PLB) have been reported to be higher in children than in adults, scarce data are available regarding pediatric patients stratified by nati...
-
Article
Open AccessClinical utility of simple subjective gait speed for the risk stratification of heart failure in a primary prevention setting
Little is known regarding the relationship between self-reported gait speed and the subsequent risk of heart failure (HF) and cardiovascular disease (CVD). We sought to clarify the clinical utility of self-rep...
-
Article
Interstitial lung disorders following postoperative radiotherapy with concurrent or sequential hormonal therapy for breast cancer: a nationwide database study in Japan
Hormonal therapy and radiotherapy are conducted concurrently or sequentially after breast cancer surgery. It remains unclear whether concurrent or sequential treatment is safer in terms of lung complications. ...
-
Article
Association between body mass index and incidence of breast cancer in premenopausal women: a Japanese nationwide database study
The association between body mass index (BMI) and the incidence of premenopausal breast cancer in the Asian population remains unclear. We investigated this association using data from a Japanese nationwide ad...
