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Open AccessB3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
B3GNT7, a glycosyltransferase of significant importance that is highly expressed in intestinal epithelial cells, plays a pivotal role in intestinal physiological processes. This study elucidates novel insights...
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Open AccessAtomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
The two-pore domain potassium (K2P) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the ...
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Open AccessCharacterization of a wheat stable QTL for spike length and its genetic effects on yield-related traits
Spike length (SL) is one of the most important agronomic traits affecting yield potential and stability in wheat. In this study, a major stable quantitative trait locus (QTL) for SL, i.e., qSl-2B, was detected in...
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Open AccessBioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury
Myocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of blood flow is essential for improving patient outcomes, the subsequen...
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Correction: Characteristic Analysis of Magnetic Gear with Copper Bar
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Open AccessDynamics of host immune responses and a potential function of Trem2hi interstitial macrophages in Pneumocystis pneumonia
Pneumocystis pneumonia (PCP) is a life-threatening opportunistic fungal infection with a high mortality rate in immunocompromised patients, ranging from 20 to 80%. However, current understanding of the variation ...
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Open AccessSelecting a preculture strategy for improving biomass and astaxanthin productivity of Chromochloris zofingiensis
Chromochloris zofingiensis is a potential source of natural astaxanthin; however, its rapid growth and astaxanthin enrichment cannot be achieved simultaneously. This study established autotrophic, mixotrophic, a...
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Open AccessMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts
The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive und...
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Article
Open AccessPAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its...
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Open AccessSelf-Supervised Learning for Industrial Image Anomaly Detection by Simulating Anomalous Samples
Industrial image anomaly detection (AD) is a critical issue that has been investigated in different research areas. Many works have attempted to detect anomalies by simulating anomalous samples. However, how t...
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Open AccessLoss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zin...
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Open AccessEfficacy and safety of neostigmine on treating gastrointestinal dysmotility in severe acute pancreatitis patients: study protocol for a randomized controlled trial
Acute pancreatitis is a serious threat to human health and gastrointestinal dysmotility is a common complication for acute pancreatitis patients, resulting in delayed feeding, oral feeding intolerance, paralyt...
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Open AccessA genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
Identification of the genes and processes mediating genetic association signals for complex diseases represents a major challenge. As many of the genetic signals for type 2 diabetes (T2D) exert their effects t...
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Open AccessAuthor Correction: QuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins
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Open AccessQuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins
Rhodopsins had long been considered non-fluorescent until a peculiar voltage-sensitive fluorescence was reported for archaerhodopsin-3 (Arch3) derivatives. These proteins named QuasArs have been used for imagi...
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Research on the spatial effects of haze pollution on public health: spatial–temporal evidence from the Yangtze River Delta urban agglomerations, China
Haze pollution poses a serious threat to residents’ health. In this study, a spatial econometric model of environmental health was established to investigate the direction, intensity, and spatial–temporal hete...
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Open AccessBak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells
Metformin (Met) exhibits anticancer ability in various cancer cell lines. This report aims to explore the exact molecular mechanism of Met-induced apoptosis in HCT116 cells, a human colorectal cancer cell line...
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Open AccessSingle-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysi...
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Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
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Open AccessLncRNA Bmp1 promotes the healing of intestinal mucosal lesions via the miR-128-3p/PHF6/PI3K/AKT pathway
Intestinal mucosal injuries are directly or indirectly related to many common acute and chronic diseases. Long non-coding RNAs (lncRNAs) are expressed in many diseases, including intestinal mucosal injury. How...
