28 Result(s)

Article

Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation

Systemic autoinflammatory disorders (SAIDs) represent a growing spectrum of diseases characterized by dysregulation of the innate immune system. The most common pediatric autoinflammatory fever syndrome, Perio...

Y. Vyzhga, H. Wittkowski, V. Hentgen, S. Georgin-Lavialle… in Pediatric Rheumatology (2024)

Article

Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever

Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been sho...

G. Varga, S. Schleifenbaum, U. Koenig, J. Waldkirch… in Molecular and Cellular Pediatrics (2023)

Article

Breaking down the fences among registries on autoinflammatory diseases: the E-Merge project

Among the various numbers of different autoinflammatory diseases (AIDs), the absolute majority of them remains rare, with a single representative in large populations. This project, endorsed by PRES, supported...

Y. Vyzhga, V. Hentgen, R. Caorsi, H. Wittkowski… in Orphanet Journal of Rare Diseases (2023)

Article

Evidenzbasierte Therapieempfehlungen für das familiäre Mittelmeerfieber

Das familiäre Mittelmeerfieber (FMF) ist eine in Deutschland seltene, genetisch bedingte Erkrankung des Kindes- und Erwachsenenalters, die durch rezidivierende Fieberschübe und klinische Zeichen von Peritoniti...

T. Kallinich, N. Blank, T. Braun, E. Feist, U. Kiltz… in Zeitschrift für Rheumatologie (2019)

Article

IL-6 blockade in systemic juvenile idiopathic arthritis – achievement of inactive disease and remission (data from the German AID-registry)

Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed...

M. Bielak, E. Husmann, N. Weyandt, J.-P. Haas, B. Hügle… in Pediatric Rheumatology (2018)

Article

Colchicine therapy in children with FMF

A-M Knieper, J Klotsche, D Föll, H Wittkowski, E Lainka… in Pediatric Rheumatology (2015)

Article

Hexameric S100A12 is required for pro-inflammatory TLR4-signalling

C Kessel, S Fühner, S Brockmeyer, H Wittkowski, D Föll in Pediatric Rheumatology (2015)

Article

Interleukin (IL)- 6 inhibition - Follow-up data of the German AID-registry¹

M Bielak, E Husmann, N Weyandt, JP Haas, G Horneff, T Lutz… in Pediatric Rheumatology (2015)

Article

Interstitial lung disease in STING-associated vasculopathy with onset in infancy (SAVI): preliminary genotype-phenotype correlation

L Malle, B Marrero, Y Liu, G Montealegre, D Chapelle, H Kim… in Pediatric Rheumatology (2015)

Article

PReS-FINAL-2216: Biomarkers MRP8/14 and S100A12 correspond with flare and remission clinical status in Sojia patients in the AID-NET register

F Gohar, E Husmann, PJ Haas, G Horneff, H Wittkowski, D Holzinger… in Pediatric Rheumatology (2013)

Article

PReS-FINAL-2215: Genotype-phenotype correlations in children with Familial Mediterranean Fever in Germany

F Gohar, M Jeske, P Lohse, T Kallinich, U Neudorf, T Niehues… in Pediatric Rheumatology (2013)

Article

PW01-009 – Markers of inflammation in adult FMF patients

A Giese, H Wittkowski, A Örnek, M Kurucay, E Lainka, BF Henning in Pediatric Rheumatology (2013)

Article

PW01-008 – The inflammasome and secretory pathways in FMF

B Orak, T Kallinich, M Lieber, H von Bernuth, H Wittkowski… in Pediatric Rheumatology (2013)

Article

OR6-001 - S100A12 as pro-inflammatory TLR4 ligand

C Kessel, H Wittkowski, A Lüken, T Weinhage, G Varga, T Vogl… in Pediatric Rheumatology (2013)