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Article
Numerical Analysis for an Energy-stable Total Discretization of a Poromechanics Model with Inf-sup Stability
We consider a previously proposed general nonlinear poromechanical formulation, and we derive a linearized version of this model. For this linearized model, we obtain an existence result and we propose a compl...
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Chapter and Conference Paper
Assessment of Atrioventricular Valve Regurgitation Using Biomechanical Cardiac Modeling
In this work we introduce the modeling of atrioventricular valve regurgitation in a spatially reduced order biomechanical heart model. The model can be fast calibrated using non-invasive data of cardiac magnet...
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Article
Open AccessDeficiency of Interleukin-1 Receptor Antagonist (DIRA): Report of the First Indian Patient and a Novel Deletion Affecting IL1RN
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Article
Open AccessPreliminary response to Janus kinase inhibition with baricitinib in chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE)
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Article
Open AccessStratification of patients with autoinflammatory phenotypes by interferon (IFN) score suggests a new group of IFN mediated autoinflammatory diseases with overlap** clinical phenotypes
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Article
Open AccessInterstitial lung disease in STING-associated vasculopathy with onset in infancy (SAVI): preliminary genotype-phenotype correlation
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Chapter and Conference Paper
Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study
We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the da...
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Chapter and Conference Paper
Sequential State Estimation for Electrophysiology Models with Front Level-Set Data Using Topological Gradient Derivations
We propose a new sequential estimation method for making an electrophysiology model patient-specific, with data in the form of level sets of the electrical potential. Our method incorporates a novel correction...
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Article
Dimensional reductions of a cardiac model for effective validation and calibration
Complex 3D beating heart models are now available, but their complexity makes calibration and validation very difficult tasks. We thus propose a systematic approach of deriving simplified reduced-dimensional m...
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Article
Direct finite element computation of non-linear modal coupling coefficients for reduced-order shell models
We propose a direct method for computing modal coupling coefficients—due to geometrically nonlinear effects—for thin shells vibrating at large amplitude and discretized by a finite element (FE) procedure. Thes...
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Article
Strong Convergence Results for the Asymptotic Behavior of the 3D-Shell Model
We revisit the asymptotic convergence properties—with respect to the thickness parameter—of the earlier-proposed 3D-shell model. This shell model is very attractive for engineering applications, in particular ...
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Article
Fundamental principles of data assimilation underlying the Verdandi library: applications to biophysical model personalization within euHeart
We present the fundamental principles of data assimilation underlying the Verdandi library, and how they are articulated with the modular architecture of the library. This translates—in particular—into the defini...
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Article
Sequential identification of boundary support parameters in a fluid-structure vascular model using patient image data
Viscoelastic support has been previously established as a valuable modeling ingredient to represent the effect of surrounding tissues and organs in a fluid-structure vascular model. In this paper, we propose a...
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Article
Estimation of tissue contractility from cardiac cine-MRI using a biomechanical heart model
The objective of this paper is to propose and assess an estimation procedure—based on data assimilation principles—well suited to obtain some regional values of key biophysical parameters in a beating heart mo...
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Article
Analytical prediction of damage in the composite part of a type-3 hydrogen storage vessel
The damage behavior of a type-3 hydrogen storage vessel is modeled. The vessel consists of a metal envelop, called liner, coated with a filament winding. The model proposed allows simulating the mechanical res...
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Article
External tissue support and fluid–structure simulation in blood flows
The objective of this work is to address the formulation of an adequate model of the external tissue environment when studying a portion of the arterial tree with fluid–structure interaction. Whereas much work...
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Chapter and Conference Paper
Trials on Tissue Contractility Estimation from Cardiac Cine MRI Using a Biomechanical Heart Model
In this paper we apply specific data assimilation methods in order to estimate regional contractility parameters in a biomechanical heart model, using as measurements real Cine MR images obtained in an animal exp...
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Chapter and Conference Paper
Constitutive Parameter Estimation Methodology Using Tagged-MRI Data
We propose a methodology for performing the estimation of a key constitutive parameter in a biomechanical heart model – namely, the tissue contractility – using tagged-MRI data. We adopt a sequential data assi...
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Article
A poroelastic model valid in large strains with applications to perfusion in cardiac modeling
This paper is motivated by the modeling of blood flows through the beating myocardium, namely cardiac perfusion. As in other works, perfusion is modeled here as a flow through a poroelastic medium. The main co...
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Chapter and Conference Paper
Simulation of 3D Ultrasound with a Realistic Electro-mechanical Model of the Heart
This paper presents a first set of experiments to integrate a realistic electro-mechanical model of a beating heart into simulated real-time three-dimensional (RT3D) ultrasound data. A novel ultrasound simulat...
