34 Result(s)

Article

Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore

Precise identification and quantification of amino acids is crucial for many biological applications. Here we report a copper(II)-functionalized Mycobacterium smegmatis porin A (MspA) nanopore with the N91H subst...

Ming Zhang, Chao Tang, Zichun Wang, Shanchuan Chen, Dan Zhang, Kaiju Li… in Nature Methods (2024)

Article

Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection

The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominan...

**gyun Yang, Weiqi Hong, Hong Lei, Cai He… in Signal Transduction and Targeted Therapy (2023)

Article

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts on the public health and the global ec...

Liyan Guo, Sheng Lin, Zimin Chen, Yu Cao… in Signal Transduction and Targeted Therapy (2023)

Article

Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants

Mucosal immunity plays a significant role in the first-line defense against viruses transmitted and infected through the respiratory system, such as SARS-CoV-2. However, the lack of effective and safe adjuvant...

Hong Lei, Aqu Alu, **gyun Yang, ** He, Cai He, Wenyan Ren… in Nature Communications (2023)

Article

Trimeric protein vaccine based on Beta variant elicits robust immune response against BA.4/5-included SARS-CoV-2 Omicron variants

The current Coronavirus Disease 2019 (COVID-19) pandemic, induced by newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants, posed great threats to global public health se...

Cai He, Li Chen, **gyun Yang, Zimin Chen, Hong Lei, Weiqi Hong… in Molecular Biomedicine (2023)

Article

A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and immune escape ability, resultin...

Cai He, **gyun Yang, Weiqi Hong, Zimin Chen, Dandan Peng… in Nature Communications (2022)

Article

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain...

Hong Lei, Aqu Alu, **gyun Yang, Wenyan Ren… in Signal Transduction and Targeted Therapy (2022)

Article

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing to host defense. Cont...

Weiqi Hong, **gyun Yang, Jun Zou, Zhenfei Bi, Cai He… in Cellular & Molecular Immunology (2022)

Article

Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response

Cai He, Xuemei He, **gyun Yang, Hong Lei… in Signal Transduction and Targeted Therapy (2022)

Article

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Sheng Lin, Zimin Chen, **ndan Zhang, Ao Wen… in Signal Transduction and Targeted Therapy (2022)

Article

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 can therefore function as a decoy. Here we ...

Fei Ye, ** Lin, Zimin Chen, Fanli Yang… in Signal Transduction and Targeted Therapy (2021)

Article

Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A Correction to this paper has been published: https://doi.org/10.1007/s00125-020-03108-4.

**gyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi… in Nature (2021)

Article

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

Hong Lei, Aqu Alu, **gyun Yang, Cai He… in Signal Transduction and Targeted Therapy (2020)

Article

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. An effective preventive vaccine ...

**gyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi… in Nature (2020)

Article

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin, Hua Chen, Fei Ye, Zimin Chen… in Signal Transduction and Targeted Therapy (2020)

Article

Active DNA unwinding and transport by a membrane-adapted helicase nanopore

Nanoscale transport through nanopores and live-cell membranes plays a vital role in both key biological processes as well as biosensing and DNA sequencing. Active translocation of DNA through these nanopores u...

Ke Sun, Changjian Zhao, **aojun Zeng, Yuejia Chen, **n Jiang… in Nature Communications (2019)

Article

Crystal structure of Usutu virus envelope protein in the pre-fusion state

Usutu virus (USUV) is a mosquito-born flavivirus that can infect multiple avian and mammalian species. The viral surface envelope (E) protein functions to initiate the viral infection by recognizing cellular r...

Zimin Chen, Fei Ye, Sheng Lin, Fanli Yang, Yanwei Cheng, Yu Cao… in Virology Journal (2018)

Article

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

The T3SS chaperone CesT is recently shown to interact with the post-transcriptional regulator CsrA to modulate post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. The molecular b...

Fei Ye, Fanli Yang, Ruijie Yu, ** Lin, Jianxun Qi, Zhujun Chen… in Nature Communications (2018)