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Article
Open AccessAvailability and use of Standards in vaccine development
Reference materials are critical in assay development for calibrating and assessing their suitability. The devasting nature of the COVID-19 pandemic and subsequent proliferation of vaccine platforms and techno...
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Article
Open AccessA super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection
Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (A...
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Article
Open AccessImplementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins
Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 disease. Therapeutic antibodies are being developed that interact with the viral spike proteins to limit viral infe...
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Article
Open AccessPassive immunisation of convalescent human anti-Zika plasma protects against challenge with New World Zika virus in cynomolgus macaques
Zika virus (ZIKV) causes neurological complications in susceptible individuals, highlighted in the recent South American epidemic. Natural ZIKV infection elicits host responses capable of preventing subsequent...
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Article
A bipartite structural organization defines the SERINC family of HIV-1 restriction factors
The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization. Here, using cryo-EM, we determine the structures of human SERINC5 ...
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Article
Open AccessHarmonization of Zika neutralization assays by using the WHO International Standard for anti-Zika virus antibody
During outbreaks of emerging viruses, such as the Zika outbreak in 2015–2016, speed and accuracy in detection of infection are critical factors to control the spread of the disease; often serological and diagn...
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Article
Open AccessIdentifying features of the lentiviral genome crucial for the establishment of latency
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Protocol
Potential Zoonotic Infection of Porcine Endogenous Retrovirus in Xenotransplantation
Porcine endogenous retrovirus (PERV) is considered the major biosafety issue in xenotransplantation. Several techniques have been employed for the analysis of the PERV status in the animal donor and for the as...
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Article
Open AccessAnti-retroviral innate immune responses in multiple lymphoid tissues elicited by protective live attenuated SIV vaccination
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Article
Open AccessDifferential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species
The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host r...
