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Article
Open AccessIntrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes
SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseli...
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Article
Open AccessBlood identified and quantified in formalin fixed paraffin embedded lung sections using eosin fluorescence
Eosin Y is a common stain in histology. Although usually used for colourimetric imaging where the dye is used to stain pink/red a range of structures in the tissue, Eosin Y is also a fluorochrome, and has been...
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Article
Open AccessPassive immunisation of convalescent human anti-Zika plasma protects against challenge with New World Zika virus in cynomolgus macaques
Zika virus (ZIKV) causes neurological complications in susceptible individuals, highlighted in the recent South American epidemic. Natural ZIKV infection elicits host responses capable of preventing subsequent...
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Article
Open AccessHigh susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species
South American Zika virus (ZIKV) recently emerged as a novel human pathogen, linked with neurological disorders. However, comparative ZIKV infectivity studies in New World primates are lacking. Two members of ...
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Article
Localization and Control of Expression of VEGF-A and the VEGFR-2 Receptor in Fetal Sheep Intestines
We studied expression of vascular endothelial growth factor A (VEGF-A) and its main receptor, VEGFR-2, in the small intestine from five groups of fetal sheep (each n = 5): 1) preterm controls, 2) term controls, 3...
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Article
Open AccessInterferon-γ increases neuronal death in response to amyloid-β1-42
Alzheimer's disease is a neurodegenerative disorder characterized by a progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately the death of neurons. The amyloid hypothesis prop...
