46 Result(s)
within
Gerd-Rüdiger Burmester
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Article
Open AccessCollating the voice of people with autoimmune diseases: Methodology for the Third Phase of the COVAD Studies
The growing recognition of holistic patient care highlights the various factors sha** the quality of life of individuals with autoimmune and rheumatic diseases (AIRDs). Beyond the traditional disease measure...
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Therapeutische Antikörper in der Rheumatologie
Mit Emil von Behrings Serumtherapie der Diphtherie wurden erstmals Antikörper therapeutisch eingesetzt. Über 100 Jahre später begann 1998 mit der Zulassung von Infliximab, eines gegen Tumor-Nekrose-Faktor‑α (T...
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Open AccessFilgotinib Demonstrates Efficacy in Rheumatoid Arthritis Independent of Smoking Status: Post Hoc Analysis of Phase 3 Trials and Claims-Based Analysis
To assess cigarette smoking’s effects on efficacy of the preferential Janus kinase (JAK) 1 inhibitor filgotinib and drug persistence in patients with rheumatoid arthritis (RA).
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Open AccessDigital health information on autoinflammatory diseases: a YouTube quality analysis
Getting access to specialists for autoinflammatory diseases (AID) can be challenging. Therefore, an increasing number of patients and healthcare professionals are seeking information on AID via the Internet, u...
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Open AccessMacrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2
Adult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. E...
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Was ist gesichert in der Therapie von autoinflammatorischen Fiebererkrankungen?
In den letzten 20 Jahren hat die Aufklärung von monogenetisch verursachten periodischen Fiebererkrankungen zum eigenständigen Konzept der Autoinflammation geführt. In diese heterogene Gruppe werden inzwischen ...
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Nachruf der Deutschen Gesellschaft für Rheumatologie auf Prof. Joachim R. Kalden
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Open AccessGolimumab as the First-, Second-, or at Least Third-Line Biologic Agent in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, or Ankylosing Spondylitis: Post Hoc Analysis of a Noninterventional Study in Germany
While golimumab (GLM) has demonstrated efficacy in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) in several randomized clinical trials with biologic-naïve patients, obse...
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Open AccessFluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period
Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies.
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Article
Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What’s the Difference?
Interleukin-6 (IL-6) signaling is a critical target in inflammatory pathways. Today, tocilizumab (TCZ) and sarilumab (SAR), two IL-6 receptor-inhibiting monoclonal antibodies, are widely used in the treatment ...
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Open AccessHypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity
Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To in...
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Open AccessFluorescence optical imaging in pediatric patients with inflammatory and non-inflammatory joint diseases: a comparative study with ultrasonography
Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wri...
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Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options
Interferon alpha and its surrogates, including IP-10 and SIGLEC1, paralleled changes of disease activity in systemic lupus erythematosus (SLE). However, the whole blood interferon signature (WBIFNS)—the curren...
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Open AccessDisturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study
Utilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the potential to identify malperfusion by little to no ti...
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Open AccessSequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid arthritis
The aim was to identify novel diagnostic autoantibody candidates for rheumatoid arthritis (RA) by comprehensive screening for autoreactivity.
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Article
A phase II investigator-initiated pilot study with low-dose cyclosporine A for the treatment of articular involvement in primary Sjögren’s syndrome
This study aims to investigate the efficacy and safety of low-dose cyclosporine A (CyA) in patients with primary Sjögren’s syndrome (pSS) and articular involvement. This phase II open-label clinical study incl...
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Open AccessA prospective pilot study to evaluate an animated home-based physical exercise program as a treatment option for patients with rheumatoid arthritis
Physical exercises and physiotherapy are of great importance for maintenance of joint function in patients with rheumatoid arthritis (RA). However, many RA patients complain about problems to receive prescript...
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Disentangling the effects of tocilizumab on neutrophil survival and function
The synovial tissue in rheumatoid arthritis (RA) represents a hypoxic environment with up-regulated pro-inflammatory cytokines and cellular infiltrates including neutrophils. Although inhibition of the interle...
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Open AccessCarbamylated vimentin represents a relevant autoantigen in Latin American (Cuban) rheumatoid arthritis patients
Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti...
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Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters
Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We...
