15 Result(s)

Article

Clinical spectrum and long-term outcomes of mpox: a cohort study spanning from acute infection to six-month follow-up

Cases of mpox have been reported worldwide since May 2022. Limited knowledge exists regarding the long-term course of this disease. To assess sequelae in terms of scarring and quality of life (QoL) in mpox pat...

Christoph Zeyen, Maria Kinberger, Helene Kriedemann… in BMC Infectious Diseases (2024)

Article

Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenoty** National Pandemic Cohort Network in Germany (NAPKON-HAP)

The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term morbidity and mortality worldwide despite global efforts in containment, prophylaxis, and ...

Fridolin Steinbeis, Charlotte Thibeault, Sarah Steinbrecher, Yvonne Ahlgrimm… in Infection (2024)

Article

Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients

Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim of this study was to e...

Silke Leonhardt, Christian Jürgensen, Josephine Frohme… in Hepatology International (2023)

Article

Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Pseudo-progression and flare-up phenomena constitute a novel diagnostic challenge in the follow-up of patients treated with immune-oncology drugs. We present a case study on pulmonary flare-up after Idecabtage...

Alexander M. Leipold, Rudolf A. Werner, Johannes Düll, Pius Jung, Mara John… in Leukemia (2023)

Article

Incidence and outcomes of SARS-CoV-2-associated PIMS in Germany: a nationwide analysis

Christian Karagiannidis, Leif-Erik Sander, Marcus A. Mall, Reinhard Busse in Infection (2022)

Article

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) o...

Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler… in Nature Communications (2022)

Article

Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies

Six to 19% of critically ill COVID-19 patients display circulating auto-antibodies against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for early identification of IFN-AAB...

Bengisu Akbil, Tim Meyer, Paula Stubbemann… in Journal of Clinical Immunology (2022)

Article

Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2

Adult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. E...

Frédéric Muench, Martin Krusche, Leif Erik Sander, Thomas Rose… in BMC Rheumatology (2021)

Article

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

SARS-CoV-2 is a single-stranded RNA virus that causes COVID-19. Given its acute and often self-limiting course, it is likely that components of the innate immune system play a central part in controlling virus...

Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Daniela Niemeyer… in Nature (2021)

Article

Ultra-fast proteomics with Scanning SWATH

Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrom...

Christoph B. Messner, Vadim Demichev, Nic Bloomfield… in Nature Biotechnology (2021)

Article

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying causes and the effects of the main anti-hyperte...

Saskia Trump, Soeren Lukassen, Markus S. Anker, Robert Lorenz Chua… in Nature Biotechnology (2021)

Article

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic^1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic i...

Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg… in Nature (2020)

Article

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically ...

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P. Hennig… in Nature Biotechnology (2020)

Article

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunolo...

Florian Kurth, Maria Roennefarth, Charlotte Thibeault, Victor M. Corman… in Infection (2020)

Article

Hämophagozytische Lymphohistiozytose bei unspezifischer Virusinfektion

Die Hämophagozytische Lymphohistiozytose (HLH), in der Literatur auch Hämophagozytosesyndrom oder Makrophagenaktivierungssyndrom im Rahmen einer rheumatologischen Vorerkrankung, wird auf Intensivstationen aufg...

Dr. med. Gunnar Lachmann, Cornelia Knaak, Paul La Rosée, Claudia Spies… in Der Anaesthesist (2019)