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Article
Open AccessA large-scale and PCR-referenced vocal audio dataset for COVID-19
The UK COVID-19 Vocal Audio Dataset is designed for the training and evaluation of machine learning models that classify SARS-CoV-2 infection status or associated respiratory symptoms using vocal audio. The UK...
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Article
Open AccessAudio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers
Recent work has reported that respiratory audio-trained AI classifiers can accurately predict SARS-CoV-2 infection status. However, it has not yet been determined whether such model performance is driven by la...
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Article
Open AccessImproving local prevalence estimates of SARS-CoV-2 infections using a causal debiasing framework
Global and national surveillance of SARS-CoV-2 epidemiology is mostly based on targeted schemes focused on testing individuals with symptoms. These tested groups are often unrepresentative of the wider populat...
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Article
Open AccessPublisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21276-3
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Article
Open AccessSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose t...
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Article
Open AccessCorrection: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessTumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group.
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Article
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
Chris Spencer, Eleanor Barnes and colleagues use human genoty** arrays and whole-genome viral sequencing to perform a systematic genome-to-genome study of 542 individuals chronically infected with hepatitis ...
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Article
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
Steve Brown and colleagues report an analysis of 20 phenoty** tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes...
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Article
New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distr...
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Article
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), ...
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Article
Open AccessA comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout ...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
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Article
Open AccessVariance decomposition of protein profiles from antibody arrays using a longitudinal twin model
The advent of affinity-based proteomics technologies for global protein profiling provides the prospect of finding new molecular biomarkers for common, multifactorial disorders. The molecular phenotypes obtain...
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Article
Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Nat. Genet. 42, 949–960 (2010); published online 10 October 2010; corrected after print 12 October 2011 In the version of this article initially published, there were errors in Table 1. Specifically, for eight...
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Article
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, s...
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Article
Evaluating Supplemental Mass Pollination Efficacy in a Lodgepole Pine Orchard in British Columbia using Chloroplast DNA Markers
Supplemental mass pollination (SMP) success in a grafted lodgepole pine (Pinus contorta Dougl. ex Loud. var. latifolia Engelm.) seed orchard in southern British Columbia was studied by employing four chloroplast ...
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Peripheral Visions (1984)
It is a pleasure to find a lighthearted work which is satisfying on many different levels and is unerringly tasteful; its humour is never misjudged or heavy. Nicholson’s piece is delightful, and both a joy and...
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Determination of UT1 and Polar Motion by the Deep Space Network using very Long Baseline Interferometry
The Deep Space Network (DSN) [operated by JPL under contract to the National Aeronautics and Space Administration] is implementing a Very Long Baseline Interferometry (VLBI) capability at DSS 63 (Spain), DSS 1...
