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  1. Article

    Open Access

    Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy

    Despite high tumour response rates to platinum-based chemotherapy in ovarian cancer survival is poor due to the emergence of drug resistance. Mechanistic studies in clinical material have been hampered by the ...

    P Wynne, C Newton, J A Ledermann, A Olaitan, T A Mould… in British Journal of Cancer (2007)

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    Article

    Evaluating Supplemental Mass Pollination Efficacy in a Lodgepole Pine Orchard in British Columbia using Chloroplast DNA Markers

    Supplemental mass pollination (SMP) success in a grafted lodgepole pine (Pinus contorta Dougl. ex Loud. var. latifolia Engelm.) seed orchard in southern British Columbia was studied by employing four chloroplast ...

    Michael Stoehr, Helga Mehl, George Nicholson, Greg Pieper, C. Newton in New Forests (2006)

  3. No Access

    Article

    Chloroplast phylogeography and evolution of highly polymorphic microsatellites in lodgepole pine (Pinus contorta)

    We employed a novel set of six highly polymophic chloroplastic simple sequence repeat (cpSSR) loci to investigate the phylogeography of lodgepole pine (Pinus contorta Dougl. Ex. Loud.), and to examine aspects of ...

    H. Dawn Marshall, C. Newton, K. Ritland in Theoretical and Applied Genetics (2002)

  4. Article

    Incidence of ocular motility problems following scleral buckling surgery

    The incidence and severity of extraocular muscle imbalance after conventional scleral buckling surgery was determined for 70 eyes of 68 patients with primary rheg-matogenous retinal detachment. Fifty-eight eye...

    A F Spencer, C Newton, S A Vernon in Eye (1993)

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  5. No Access

    Article

    Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients

    The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in postmenopausal breast cancer patients and to achieve clinical responses at a dose of 500 mg ...

    M Dowsett, F MacNeill, A Mehta, C Newton, B Haynes, A Jones… in British Journal of Cancer (1991)

  6. No Access

    Article

    ΔF508 testing of the DNA bank of the Royal Manchester Children's Hospital

    Details of haplotype and ΔF508 status from various populations represented in the cystic fibrosis (CF) DNA bank of the Royal Manchester Children's Hospital are provided, together with information on the associ...

    M. J. Schwarz, M. Super, C. Wallis, P. Beighton, C. Newton… in Human Genetics (1990)

  7. No Access

    Chapter

    Immunoadjuvanticity of Endotoxins and Nontoxic Derivatives for Normal and Leukemic Immunocytes

    Endotoxins from many Gram negative bacteria are known to be immunostimulators. For example, administration of crude or even purified lipopolysaccharide (LPS) endotoxin preparations into experimental animals ch...

    H. Friedman, T. Klein, S. Specter, C. Newton, A. Nowotny in Endotoxin (1990)