19 Result(s)
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Friedrich Götz
Microbiology
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Article
Journal Club
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Article
Open AccessStaphylococcus carnosus: from starter culture to protein engineering platform
Since the 1950s, Staphylococcus carnosus is used as a starter culture for sausage fermentation where it contributes to food safety, flavor, and a controlled fermentation process. The long experience with S. carno...
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Article
Wie bakterielle Moleküle unser Immunsystem manipulieren
Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infec...
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Article
Excretion of cytoplasmic proteins in Staphylococcus is most likely not due to cell lysis
The excretion of cytoplasmic proteins (ECP) is a long-known phenomenon in bacteria and eukaryotes. So far, it was not possible to associate either a signal peptide-dependent or a signal peptide-independent pat...
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Article
Inhibition of staphylococcal biofilm-related gene transcription by rhodomyrtone, a new antibacterial agent
Biofilms are one of the most important staphylococcal virulence factors, which are often associated with antibiotic resistance in the organisms. Our previous studies have demonstrated that rhodomyrtone from Rhodo...
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Article
Open AccessRole of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus
Bacterial protein biosynthesis usually depends on a formylated methionyl start tRNA but Staphylococcus aureus is viable in the absence of Fmt, the tRNAMet formyl transferase. fmt mutants exhibit reduced growth ra...
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Chapter
Staphylococcal Virulence Factors
The adherence of staphylococci to the unmodified or host factor-coated surface of a medical device is the first critical event in the establishment of a device-associated infection with these serious pathogens. S...
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Article
Open AccessTranscriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures
Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial s...
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Article
Open AccessThe GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses
Modification of teichoic acids with D-alanine by the products of the dlt operon protects Gram-positive bacteria against major antimicrobial host defense molecules such as defensins, cathelicidins, myeloperoxidase...
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Reference Work Entry In depth
The Genera Staphylococcus and Macrococcus
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Article
Secretion of human growth hormone by the food-grade bacterium Staphylococcus carnosus requires a propeptide irrespective of the signal peptide used
Staphylococcal exoproteins can be divided into two groups. One group comprises proteins bearing only a signal peptide, the other group requires an additional propeptide for secretion. The secretion signals of...
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Article
Inducible expression and cellular location of AgrB, a protein involved in the maturation of the staphylococcal quorum-sensing pheromone
AgrB has been suggested to be responsible for the posttranslational modification in staphylococci that leads to the production of the thiolactone-containing agr peptide pheromone. We demonstrate that AgrB is loc...
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Article
Cloning, sequencing, and characterization of a gene (narT) encoding a transport protein involved in dissimilatory nitrate reduction inStaphylococcus carnosus
A Tn917 mutant ofStaphylococcus carnosus TM300, nrIII, was isolated and characterized. Mutant nrIII did not take up nitrate or accumulate nitrite when grown in B-medium supplemented with up to 10 mM nitrate under...
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Article
The biosynthesis of the lantibiotics epidermin, gallidermin, Pep5 and epilancin K7
Lantibiotics are antibiotic peptides that contain the rare thioether amino acids lanthionine and/or methyllanthionine. Epidermin, Pep5 and epilancin K7 are produced by Staphylococcus epidermidis whereas galliderm...
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Article
Protein engineering of lantibiotics
Whereas protein engineering of enzymes and structural proteins nowadays is an established research tool for studying structure-function relationships of polypeptides and for improving their properties, the eng...
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Article
Post-translational modifications of lantibiotics
Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes i...
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Article
Lipase production of Staphylococcus carnosus in a dialysis fermentor
In a newly constructed one-vessel dialysis fermentor, a strain of Staphylococcus carnosus TM300 carrying the lipase secretion plasmid pLipPS1 was used to investigate exoenzyme and biomass production. The bacteria...
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Article
Cloning of the ribokinase gene of Staphylococcus hyicus subsp. hyicus in Staphylococcus carnosus
A gene library with DNA of Staphylococcus hyicus subsp. hyicus was established in S. carnosus by using the plasmid vector pCT20. Two clones of S. carnosus were isolated which were able to ferment d-ribose. The tw...
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Article
Purification and properties of a fructose-1,6-diphosphate activated l-lactate dehydrogenase from Staphylococcus epidermidis
l-(+)-lactate dehydrogenase (LDH) from Staphylococcus epidermidis ATCC 14990 was purified by affinity chromatography. The purified enzyme was specifically activated by fructose-1,6-diphosphate (FDP). The concent...
