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Open AccessMARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes
The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane proteins. MARCH8 has been reported to inhibit the infection of HIV-1 and a few other vir...
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Article
Open AccessAmphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry
Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease that leads to cardiopulmonary complications and death in young children. There is thus an urgent need to find new treatments to control EV71 i...
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Article
Open AccessBoHV-4 immediate early 1 gene is a dispensable gene and its product is not a bone marrow stromal cell antigen 2 counteracting factor
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus whose genome was cloned as Bacterial Artificial Chromosome (BAC) and exploited as a gene delivery vector for vaccine purposes. Although BoHV-4 genome has bee...
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Article
Open AccessThe interferon-induced MxB protein inhibits an early step of HIV-1 infection
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Open AccessIdentification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu
BST-2 (bone marrow stromal cell antigen 2) is an interferon-inducible protein that inhibits virus release by tethering viral particles to the cell surface. This antiviral activity of BST-2 is antagonized by HI...
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Article
Torrential rainfall responses to radiation and ice clouds over Jiang-Huai Valley, China in July 2007
The effects of radiation and ice clouds on a torrential rainfall event of Jiang-Huai Valley over China are investigated through a series of two-dimensional sensitivity cloud-resolving model experiments. The mo...
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Article
Open AccessTetherin inhibits prototypic foamy virus release
Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses. However, the ...