-
Article
Open AccessA comprehensive AI model development framework for consistent Gleason grading
Artificial Intelligence(AI)-based solutions for Gleason grading hold promise for pathologists, while image quality inconsistency, continuous data integration needs, and limited generalizability hinder their ad...
-
Article
Medical image foundation models in assisting diagnosis of brain tumors: a pilot study
To build self-supervised foundation models for multicontrast MRI of the whole brain and evaluate their efficacy in assisting diagnosis of brain tumors.
-
Article
Open AccessMpox (formerly monkeypox): pathogenesis, prevention, and treatment
In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions. The World Health Organization declared...
-
Article
Open AccessA cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted c...
-
Article
Open AccessUncovering potential diagnostic biomarkers of acute myocardial infarction based on machine learning and analyzing its relationship with immune cells
Acute myocardial infarction (AMI) is a common cardiovascular disease. This study aimed to mine biomarkers associated with AMI to aid in clinical diagnosis and management.
-
Article
Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC), a lethal subset of prostate cancer, is characterized by loss of AR signaling and resulting resistance to AR-targeted therapy during neuroendocrine transdifferentiation, f...
-
Article
Open AccessKRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway
Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and me...
-
Article
Candidate gene analysis of watermelon stripe pattern locus ClSP ongoing recombination suppression
Using two segregating population, watermelon stripe pattern underlying gene ClSP was delimited to a 611.78 Kb region, consisting of four discrete haplobloc...
-
Article
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling
Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around, and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC). Despite widespread recogn...
-
Article
Isolation and characterization of a recombinant Muscovy duck parvovirus circulating in Muscovy ducks in South China
In 2019, flocks of Muscovy ducks presented with clinical signs typical of MDPV infection. The MDPV GD201911 strain was isolated by inoculating samples from positive birds into Muscovy duck embryos. Challenge w...
-
Article
High expression of microRNA20b is associated with malignant clinicopathological features and poor prognosis in breast phyllodes tumor
microRNAs, which expound the transcriptional regulation of gene expression, have been validated as prognostic markers in many tumors. The deregulated expression of microRNAs has been shown to aid classificatio...
-
Article
Isolation and Characterization of A Novel Fowl Adenovirus Serotype 8a Strain from China
Since 2012, the clinical cases of inclusion body hepatitis showed an increasing trend in China, causing considerable economic losses to the poultry industry. In this study, a fowl adenovirus strain CH/GDLZ/201...
-
Article
MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness
The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells....
-
Article
Open AccessMikania micrantha genome provides insights into the molecular mechanism of rapid growth
Mikania micrantha is one of the top 100 worst invasive species that can cause serious damage to natural ecosystems and substantial economic losses. Here, we present its 1.79 Gb chromosome-scale reference genome. ...
-
Article
Open AccessA risk factor for early wheezing in infants: rapid weight gain
The aim of this study was to investigate the correlation between rapid weight gain and early wheezing.
-
Article
Open AccessEpidemiological investigation of fowl adenovirus infections in poultry in China during 2015–2018
Fowl adenoviruses (FAdVs) are associated with many diseases, resulting in huge economic losses to the poultry industry worldwide. Since 2015, outbreaks of FAdV infections with high mortality rates have been re...
-
Article
Open AccessGlucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice
Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and pro...
-
Article
Open AccessThe chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids
Sub-therapeutic antibiotics are widely used as growth promoters in the poultry industry; however, the resulting antibiotic resistance threatens public health. A plant-derived growth promoter, Macleaya cordata ext...
-
Article
Research on the Evolution Method of Domain Ontology Based on DBpedia
Domain ontology is a model that regulates the core knowledge of domain description and semantic organization, which changes along with the change of domain knowledge. Automated or semi-automated evolution appr...
-
Article
Open AccessDefective autophagy leads to the suppression of stem-like features of CD271+ osteosarcoma cells
As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a...
