-
Article
Open AccessRetraction Note: Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells
-
Article
Open AccessRoles of extracellular vesicles in periodontal homeostasis and their therapeutic potential
Periodontal tissue is a highly dynamic and frequently stimulated area where homeostasis is easily destroyed, leading to proinflammatory periodontal diseases. Bacteria–bacteria and cell–bacteria interactions pl...
-
Article
Open AccessCorrection: The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth
-
Article
Open AccessMetformin combats high glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells via inhibition of the NPR3-mediated MAPK pathway
High glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) has long been a challenge to periodontal regeneration for diabetic individuals. Metformin is an a...
-
Article
Open AccessLncRNA GACAT2 binds with protein PKM1/2 to regulate cell mitochondrial function and cementogenesis in an inflammatory environment
Periodontal ligament stem cells (PDLSCs) are a key cell type for restoring/regenerating lost/damaged periodontal tissues, including alveolar bone, periodontal ligament and root cementum, the latter of which is...
-
Article
Open AccessMelatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Stem cells that have undergone long-term ex vivo expansion are most likely functionally compromised (namely cellular senescence) in terms of their stem cell properties and therapeutic potential. Due to its abi...
-
Article
Open AccessSuppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia
Robust activation of glial cells has been reported to occur particularly during the pathogenesis of bone cancer pain (BCP). Researchers from our group and others have shown that histone deacetylases (HDACs) pl...
-
Article
Open AccessThe proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth
Although dental pulp stem cells (DPSCs) isolated from periodontally compromised teeth (P-DPSCs) have been demonstrated to retain pluripotency and regenerative potential, their use as therapeutics remains large...
-
Article
Open AccessRETRACTED ARTICLE: Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells
Accumulating evidence indicates that the pluripotency of periodontal ligament stem cells (PDLSCs) is compromised under inflammatory conditions; however, the underlying mechanisms remain largely unexplored. In ...
-
Article
Open AccessCorrection to: Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial
The original article [1] contains a major error carried across the captions of Tables 1, 2, and 3. In each table caption, the data were expressed as “mean ± standard deviation (SD)”; unfortunately, the authors...
-
Article
Open AccessExosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats
Traumatic brain injury (TBI) is one of the major causes of mortality and disability for all ages worldwide. Mesenchymal stem cells (MSCs)-originated exosomes have provided therapeutic effects. However, as an i...
-
Article
Open AccessInfluences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture
Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability and regenerative potential. Recently, the immunomodulatory influence of MSCs has...
-
Article
Effects of short-term inflammatory and/or hypoxic pretreatments on periodontal ligament stem cells: in vitro and in vivo studies
In this study, we extensively screened the in vitro and in vivo effects of PDLSCs following short-term inflammatory and/or hypoxic pretreatments. We found that the 24-h hypoxic pretreatment of PDLSCs significa...
-
Article
Open AccessThe use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering
Periodontal regeneration involves the restoration of at least three unique tissues: cementum, periodontal ligament tissue (PDL) and alveolar bone tissue. Here, we first isolated human PDL stem cells (PDLSCs) a...
-
Article
Open AccessTreatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial
Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and the leading cause of tooth loss in adults. Evidence from preclinical trials and sm...
-
Article
Potential dental pulp revascularization and odonto-/osteogenic capacity of a novel transplant combined with dental pulp stem cells and platelet-rich fibrin
Our aim is to investigate the cytobiological effects of autologous platelet-rich fibrin (PRF) on dental pulp stem cells (DPSCs) and to explore the ectopic and orthotopic possibilities of dental pulp revascular...
-
Article
Open AccessMesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway
Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...
-
Article
The use of calcium phosphate-based biomaterials in implant dentistry
Since calcium phosphates (CaPs) were first proposed, a wide variety of formulations have been developed and continuously optimized, some of which (e.g. calcium phosphate cements, CPCs) have been successfully c...
-
Chapter and Conference Paper
Synergistic Effects of Mechanical Pressure and Estrogen on the Proliferation and Alkaline Phosphatase Activity of Mandibular Condylar Chondrocytes
Mechanical stimualtions and estrogen play an important role in the formation and maintenance of normal functions in the micro-environment of cartilage.In this study, we investigated the synergistic effect of m...
-
Article
Composite glycidyl methacrylated dextran (Dex-GMA)/gelatin nanoparticles for localized protein delivery
Localized delivery of growth factors has significant potential as a future therapeutic strategy in tissue engineering and regenerative medicine. A nanoparticle vehicle was created and evaluated in this study w...