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  1. No Access

    Article

    Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments

    The development of network inference methodologies that accurately predict connectivity in dysregulated pathways may enable the rational selection of patient therapies. Accurately inferring an intracellular ne...

    Michelle L. Wynn, Megan Egbert, Nikita Consul… in Bulletin of Mathematical Biology (2018)

  2. Article

    Open Access

    Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling

    Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. All IBC patients have lymph node involvement and one-third of patients already have distant metastasis at diagnosis. This propensity f...

    Steven G. Allen, Yu-Chih Chen, Julie M. Madden, Chelsea L. Fournier… in Scientific Reports (2016)

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  3. Article

    Composite glycidyl methacrylated dextran (Dex-GMA)/gelatin nanoparticles for localized protein delivery

    Localized delivery of growth factors has significant potential as a future therapeutic strategy in tissue engineering and regenerative medicine. A nanoparticle vehicle was created and evaluated in this study w...

    Fa-ming Chen, Zhi-wei Ma, Guang-ying Dong, Zhi-fen Wu in Acta Pharmacologica Sinica (2009)

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  4. Article

    Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics

    To prepare new pharmaceutical forms with sustained delivery properties of recombinant human bone morphogenetic protein-2 (rhBMP2) for tissue engineering and guided tissue regeneration (GTR) use.

    Fa-ming Chen, Zhi-fen Wu, Qin-tao Wang, Hong Wu… in Acta Pharmacologica Sinica (2005)

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  5. No Access

    Article

    RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast

    Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified Rho...

    Celina G. Kleer, Kent A. Griffith, Michael S. Sabel… in Breast Cancer Research and Treatment (2005)

  6. No Access

    Article

    RhoC Induces Differential Expression of Genes Involved in Invasion and Metastasis in MCF10A Breast Cells

    Inflammatory breast cancer (IBC) is the most deadly form of breast cancer in humans presumably due to its ability to metastasize from its inception. In our laboratory, overexpression of RhoC GTPase was observe...

    Mei Wu, Zhi-Fen Wu, Chandan Kumar-Sinha… in Breast Cancer Research and Treatment (2004)

  7. Article

    WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer

    Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We found concordant and consistent alterations of two genes in 90% of IBC tumors when compared with stage-matched non...

    Celina G Kleer, Yanhong Zhang, Quintin Pan, Gary Gallagher… in Breast Cancer Research (2003)

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  8. No Access

    Article

    Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer

    Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the p...

    Kenneth L. van Golen, Li Wei Bao, Quintin Pan… in Clinical & Experimental Metastasis (2002)

  9. No Access

    Article

    WISP3 is a novel tumor suppressor gene of inflammatory breast cancer

    Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a 5-year disease-free survival of less than 45%. Little is known about the genetic alterations that result in IBC. In our previous w...

    Celina G Kleer, Yanhong Zhang, Quintin Pan, Kenneth L van Golen, Zhi-Fen Wu… in Oncogene (2002)

  10. Article

    Microarray analysis of RhoC-transformed mammary epithelial cells suggests molecular mechanisms of inflammatory breast cancer

    Sofia Merajver, Zhi-Fen Wu, Tammy Chang, Hamid Mirshahidi, Paul Meltzer… in Nature Genetics (2001)

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